Important notice
The course guide is provisional.
The PDF version of the course guide may take a few days to become available in the DDD.
Genomics
Code: 45552Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Biochemistry, Molecular Biology and Biomedicine | OP | 1 |
Contact lecturer
- Name :
- Jaime Martinez Urtaza
- Email :
- jaime.martinez.urtaza@uab.cat
Teaching staff
- Antoni Barbadilla Prados
- Sònia Casillas Viladerrams
- Marta Puig Font
- Barbara Negre De Bofarull
- María Pilar Garcia Guerreiro
Teaching staff (external to UAB)
- Marina Laplana Lafaja
Group languages
You can consult this information at the end of the document.
Prerequisites
Languages: Lectures will be mainly in English.
Postgraduates in Biochemistry, Biotechnology, Biology, Biomedicine, Genetics, Microbiology, Chemistry, Informatics/Bioinformatics, Pharmacy, Medicine and Veterinary Medicine
Objectives
The overall aim of the subject is to provide students an overview of genomics including fundamentals, current techniques and applications. The specific objectives include understanding the following aspects: the diversity and complexity of eukaryotic genomes, the historical and evolutionary perspective of genomic content, the meaning and consequences of intraspecific variability, techniques commonly employed in studies of genomics, metagenomics and transcriptomics and applications derived from the knowledge provided by this science.
Learning outcomes
- CA07 (Integrate genomic analysis methodologies into comparative genomics research projects.) Integrate genomic analysis methodologies into comparative genomics research projects.
- CA08 (Act ethically when combining functional and transcriptional genomics and understand the consequences of intraspecific variability.) Act ethically when combining functional and transcriptional genomics and understand the consequences of intraspecific variability.
- KA10 (Describe the different methodologies, techniques and tools commonly used in the sequencing, assembly and annotation of genomes.) Describe the different methodologies, techniques and tools commonly used in the sequencing, assembly and annotation of genomes.
- KA11 (Define the organisation, evolution, expression and population variation of the human genome.) Define the organisation, evolution, expression and population variation of the human genome.
- KA12 (Write critical summaries of seminars, demonstrating an understanding of the diversity and complexity of genomes.) Write critical summaries of seminars, demonstrating an understanding of the diversity and complexity of genomes.
- SA10 (Analyse the role of genetic alterations as dynamic genome mechanisms.) Analyse the role of genetic alterations as dynamic genome mechanisms.
- SA11 (Identify scientific solutions for research-related problems at the genome level and according to the complexity of organisms.) Identify scientific solutions for research-related problems at the genome level and according to the complexity of organisms.
- SA12 (Demonstrate communicative skills when presenting seminars on genomics, rigorously and clearly drawing on scientific information and terminology.) Demonstrate communicative skills when presenting seminars on genomics, rigorously and clearly drawing on scientific information and terminology.
Contents
Introduction to Genomics.
The human Genome.
Genomic Technologies.
Metagenomics
Transposable Elements.
Comparative Genomics: Chromosomal changes.
Comparative Genomics: Nucleotide sequence changes.
Structural variation.
Population Genomics: Theory.
Population Genomics: Data. Studies in Model Species.
Population Genomics in Humans.
Association Studies/System genetics.
Functional Genomics and Transcriptomics.
Epigenomics.
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Oral presentations | 8 | 0.32 | CA07, KA10, SA11, SA12 |
| Student work, reading and learning | 118 | 4.72 | SA10, SA11 |
| Lectures | 24 | 0.96 | CA07, CA08, KA10, KA11, KA12, SA10, SA11 |
Subject teaching includes three types of activities:
- Lectures. Spoken explanations of the subject that is to be learned accompanied by powerpoint presentations to help students visualize cuestions and answers.
- Reading and discussion. Students are expected to read a number of research papers during the course and participate in the critical discussion of the papers in the class room.
- Oral presentations. Students will prepare a subject and make an oral and powerpoint presentation of the subject to their their peers.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Lecture attendance and participation | 20% | 0 | 0 | CA07, CA08, KA12 |
| Exam | 40% | 0 | 0 | CA07, CA08, KA10, KA11, SA10, SA11 |
| Oral presentations | 40% | 0 | 0 | CA07, CA08, KA11, SA10, SA11, SA12 |
Final grades are a weighed average of following items:
- Attendance and participation in the classroom (20%)
- Oral presentation and defense (40%)
- Exam (40%)
For this subject, the use of Artificial Intelligence (AI) technologies is allowed exclusively in support tasks, such as bibliographic or information search, text correction or translations. The student will have to clearly identify which parts have been generated with this technology, specify the tools used and include a critical reflection on how they have influenced the process and the final result of the activity. Non-transparency of the use of AI in this assessable activity will be considered a lack of academic honesty and may result in a partial or total penalty in the grade of the activity, or greater penalties in cases of seriousness
Not assessable
Students will be graded as \"Not assessed\" when the weight of the evaluation in which they have participated is less than the equivalent of 50% of the final grade of the module.
Any irregularity committed during an assessment activity (academic fraud, plagiarism, or the improper use of AI—unless such use is expressly authorized in the course syllabus) that could lead to a significant change in the grade will result in that activity being graded as a 0. If the course syllabus stipulates that passing the subject requires a minimum grade in that specific assessment activity, or if multiple irregularities occur across assessment activities for the same subject, the final grade for the subject will be 0. Furthermore, disciplinary proceedings may be initiated against any student who commits such irregularities.
Bibliography
Basic books
- Gibson, G. & S. V. Muse, 2009 (3rd edition). A Primer of Genome Science. Sinauer, Massachusetts. USA.
- Brown, T. A. 2023. Genomes 5 (5th edition). Garland Science, New York, USA.
- Lesk, A.M. 2017. Introduction to genomics (3rd edition). Oxford University Press, Oxford, UK.
- Lynch, M. 2007. The origins of genome architecture. Sinauer.
- Strachan, T. & A. Lucassen, 2023. Genetics and Genomics in Medicine (2nd edition). CRC Press
Useful links
Entrez Genome Database: http://www.ncbi.nlm.nih.gov/genome
Software
NA
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TEm) Theory (master) | 1 | English | first semester | afternoon |