Important notice
The course guide is provisional.
The PDF version of the course guide may take a few days to become available in the DDD.
New Developments in Cytogenetics and Biology of Reproduction
Code: 42941Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Cytogenetics and Reproductive Biology | OB | 1 |
Contact lecturer
- Name :
- Ignasi Roig Navarro
- Email :
- ignasi.roig@uab.cat
Teaching staff
- Marta Martin Flix
- Berta Nieves Vazquez Prat
- Jose Ramon Palacio Cornide
- Mariona Terradas Ill
- Antonio Iborra Obiols
- Joan Blanco Rodriguez
- Maria Oliver Bonet
- Jordi Camps Polo
- Ester Anton Martorell
Teaching staff (external to UAB)
- Cristina Hernando
Group languages
You can consult this information at the end of the document.
Prerequisites
The same prerequisites for admission to the Master
Objectives
This is a compulsory course that aims to introduce the latest concepts and methodologies related to the fields of cytogenetics and reproductive biology for all students taking the Masters in Cytogenetics and Reproductive Biology.
The specific goals of the course are:
1.-Understand the structure, regulation and orgaització of the mammalian genome.
2.-Understand the process of differentiation and interaction of mammalian gametes that leads to the formation of an embryo.
Learning outcomes
- CA01 (Interpret the results of complex cytogenetic and molecular analyses, and their relevance in the context of human pathophysiology from an integrative perspective.) Interpret the results of complex cytogenetic and molecular analyses, and their relevance in the context of human pathophysiology from an integrative perspective.
- CA02 (Justify the use of advanced experimental methodologies for the study of chromosomal organisation and reproductive biology, considering criteria of quality, reproducibility and technical feasibility.) Justify the use of advanced experimental methodologies for the study of chromosomal organisation and reproductive biology, considering criteria of quality, reproducibility and technical feasibility.
- KA01 (Provide a detailed description of the cellular and molecular processes involved in male and female gametogenesis.) Provide a detailed description of the cellular and molecular processes involved in male and female gametogenesis.
- KA02 (Explain the mechanisms regulating the interaction between gametes and zygote activation, as well as the fundamental processes of pre-implantation embryonic development.) Explain the mechanisms regulating the interaction between gametes and zygote activation, as well as the fundamental processes of pre-implantation embryonic development.
- KA03 (Analyse the immunological aspects involved in reproduction, from the immunology of the reproductive tracts to embryo implantation.) Analyse the immunological aspects involved in reproduction, from the immunology of the reproductive tracts to embryo implantation.
- KA04 (Explain the organisation of chromatin fibre and nuclear architecture, relating them to the regulation of gene expression in higher eukaryotes.) Explain the organisation of chromatin fibre and nuclear architecture, relating them to the regulation of gene expression in higher eukaryotes.
- KA05 (Analyse the epigenetic mechanisms that regulate chromosomal function and their involvement in human pathophysiology.) Analyse the epigenetic mechanisms that regulate chromosomal function and their involvement in human pathophysiology.
- KA06 (Interpret the origin and recurrence of human pathologies associated with chromosomal alterations, integrating knowledge of clinical cytogenetics.) Interpret the origin and recurrence of human pathologies associated with chromosomal alterations, integrating knowledge of clinical cytogenetics.
- SA01 (Interpret the results from research related to genome organisation, gametogenesis and fertilisation.) Interpret the results from research related to genome organisation, gametogenesis and fertilisation.
Contents
Unit 1: Advanced Complements in Cytogenetics. Organization of chromatin fiber: in silico and in vivo studies. Chromosome territories, nuclear architecture and gene regulation in higher eukaryotes. Epigenetic regulation of chromosome function. Origin and recurrence of human diseases caused by chromosomal abnormalities.
Unit 2: Advanced Complements in Reproductive Biology. Cellular and molecular aspects of male and female gametogenesis. Acquisition of the fertilizing capacity of sperm. Mechanisms of interaction between male and female gametes. Immunology of male and female reproductive tract.
*Unless the requirements enforced by the health authorities demand a prioritization or reduction of these contents.
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Lectures | 32 | 1.28 | CA01, CA02, KA01, KA02, KA03, KA04, KA05, KA06, SA01 |
| Study | 104 | 4.16 | CA01, KA03, KA04, KA05, KA06, SA01 |
The contents of this course include lectures, taught by academics and / or professionals, which will encourage student participation.
*The proposed teaching methodology may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Written test | 80% | 4 | 0.16 | CA01, CA02, KA01, KA02, KA03, KA04, KA05, KA06, SA01 |
| Participacition in the classroom | 20% | 10 | 0.4 | CA01, CA02, KA01, KA02, KA03, KA04, KA05, KA06, SA01 |
The skills of this course will be evaluated in two sections:
1.-Written test (80% of grade): two multiple-choice test will evaluate the knowledge acquired by each student. The mark obtained in each test will represent 40% of the final mark. These tests will be performed at the end of the program contents.
2-Participation in class (20% of grade): An evaluation of student participation during lectures in the debates raised by professors will be performed.
*Student’s assessment may experience some modifications depending on the restrictions to face-to-face activities enforced by health authorities.
Unique assessment
This subject foresees the single assessment system. In this sense, this consists of a single synthesis test that will be done to coincide with the same date fixed in the calendar for the last continuous assessment test (2nd partial) and the same system will be applied in case of need for recovery.
The commission of any irregularity in an assessment act (academic fraud, plagiarism or improper use of AI, unless this use is expressly authorized in the teaching guide), which may lead to a significant variation in the grade, means that this act will be graded with a 0. In the event that the teaching guide provides that in order to pass the subject it is an essential requirement to have obtained a minimum grade in this assessment act or that several irregularities occur in the assessment acts of the same subject, the final grade for this subject is 0. Apart from this, a disciplinary process may be initiated against the student who incurs any of these irregularities.
Students will obtain the grade of Not Assessable when all of the assessment activities carried out have a weight of less than 67% of the final grade.
Bibliography
River RM, Bennet LB. Epipgenetics in humans: an overview. Curr Opin Endocrinol Diabetes Obse. 2010. 17(6):493-9
Editorial i articles inclosos a Mol Hum Reprod. 2010. 16 (1):1-56
Chowdhury D, Choi YE, Brault ME. Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol. 2013. 14(3):181-9
Hoeijmakers JHJ. Genome maintenance mechanisms for preventing cancer. Nature. 2001. 411(6835):366-74
Girirajan S, Dennis MY, Baker C, Malig M, Coe BP, Campbell CD, Mark K, Vu TH, Alkan C, Cheng Z, Biesecker LG, Bernier R, Eichler EE. Refinement and Discovery of New Hotspots of Copy-Number Variation Associated with Autism Spectrum Disorder. Am J Hum Genet . 2013. 92, 221–237
Mefford EC, Eichler EE. Duplication hotspots, rare genomic disorders, and common disease. Current Op in Genetics & Development. 2009. 19:196–204
Miller TD, Adam MP, Aradhya S, Biesecker LG, Brothman AR et al. Consensus Statement: Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies. Am J Hum Genet. 2010. 86: 749-764.
Rodriguez-Santiago B, Armengol Ll. Tecnologías de secuenciación de nueva generación en diagnóstico genético pre- y postnatal. Diagnóstico prenatal. 2012. 23 (2): 56-66
Cooper GM, Coe BP, Girirajan S, Rosenfeld JA, Vu TH et al. A copy number variation morbidity map of developmental delay. Nature Genetics. 2011. 43 (9): 838-846.
The Nucleus. Edited by Tom Misteli, National Cancer Institute/National Institutes of Health; David L. Spector, Cold Spring Harbor Laboratory. Cold Spring Harbor Laboratory Press
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms. 2012. 1819 (7): 631-846(July2012). Special issue: Chromatin in time and space
Boulcun-Filas E, Schimenti J. Genetics of meiosis and recombination in mica. Int Rev Cell Mol Biol. 2012. 298:179-227
Nagaoka SI, Hassold TJ, Hunt PA. Human aneuploidy: mechanisms and new insights into an age-old problem. Nat Rev Genet. 2012. 13 (7):493-504
Jessberger R. Age-related aneuploidy through cohesion exhaustion. EMBO Rep. 2012. 13 (6): 539-46
Software
No specific software is used in this module.
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TEm) Theory (master) | 1 | Catalan/Spanish | first semester | morning-mixed |