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Biomolecular Chemistry

Code: 100878
Credits: 6
2026/2027
Degree programme Type Course
Biochemistry OP 4

Contact lecturer

Name :
Sira Defaus Fornaguera
Email :
sira.defaus@uab.cat

Group languages

You can consult this information at the end of the document.

Prerequisites

Students are required to have successfully completed the courses Fundamentals of General Chemistry and Organic Chemistry of Biochemical Processes.

Objectives


The general aim of the Biomolecular Chemistry course is to provide students with an overview of natural products, including their structural, biosynthetic, and ecological characteristics, as well as their applications as sources of bioactive compounds. The course introduces the fundamental concepts underlying the chemical structures and biosynthesis of the major classes of natural products, together with their biological functions and their use as pharmaceuticals and agrochemicals.


The learning objectives of the course are:

  1. Understand the structures and biosynthetic pathways of natural products derived from secondary metabolism.
  2. Recognize the importance of natural products because of their biological and pharmacological activities.
  3. Understand the ecological, pharmacological, and agrochemical significance of natural products.
  4. Propose plausible biosynthetic pathways for the formation of natural products.


Learning outcomes

  • KM03 (Describe the reaction and chemical mechanisms of attraction, communication and defence in living organisms.) Describe the reaction and chemical mechanisms of attraction, communication and defence in living organisms.
  • KM04 (Define the main analytical techniques used in the study of functional groups present in biomolecules and metabolites.) Define the main analytical techniques used in the study of functional groups present in biomolecules and metabolites.
  • SM02 (Apply the main techniques used in the study of functional groups present in biomolecules and metabolites.) Apply the main techniques used in the study of functional groups present in biomolecules and metabolites.

Contents


Biosynthetic pathways

Primary and secondary metabolism. Main biosynthetic pathways: shikimate, acetate, mevalonate. Determination of biogenetic sequences. Detection of biologically active metabolites. Bioassays. Isolation and separation. Summary of reactions.


Fatty acids and polyketides

Carbohydrates. The acetate hypothesis. Saturated fatty acids. Unsaturated fatty acids. Prostaglandins. Aromatic polyketides. Macrolides.


Terpenoids

Structural classification. The route acetate-mevalonate. Monoterpenes. Sesquiterpenes. Diterpenes. Steroids. Carotenoids.


Derivatives of shikimic acid

Phenolic compounds. Aromatic amino acids (tryptophan, phenylalanine, tyrosine) and derivatives. Transamination, NIH shift. Cinnamic acids and derivatives. Pharmacological applications: L-DOPA, chloramphenicol, salicin as a model of aspirin. Lignans and lignin. Flavonoids.


Semiochemicals

Ecological chemistry. Classification of semiochemicals. Plant-insect interactions. Allelopathy. Phytoalexin. Pheromones. Types of pheromones. Structural diversity. Isolation. Practical applications of insect pheromones.


Secondary metabolism of amino acids

Prebiotic formation of amino acids. Beta-lactamic antibiotics, penicillins, cephalosporins; biogenesis and synthetic approaches.


Alkaloids I

Alkalois derived from ornithine, lysine and nicotinic acid.

Alkaloids derived from the shikimate pathway (from phenylalanine and tyrosine).

Physiological effects and pharmacological applications of alkaloids such as cocaine, nicotine, hyoscyamine, hyoscine, atropine, ephedrine, mescaline.


Alkaloids II

Alkaloids of type benzylisoquinoline: papaverine,tubocurarin (curare).

Alkaloids of modified benzylisoquinoline: opium alkaloids or morfinans (thebaine, morphine, codeine), biosynthesis and physiological effects.

Simple alkaloids derived from tryptophan (serotonin).

Alkaloids derived from tryptophan: the ergot alkaloids (lysergic acid).

Alkaloids derived from tryptophan of type indole-terpenoid (brucine, strychnine).

Alkaloids derived from tryptophan of type quinoline (quinine against malaria).

Purine alkaloids: caffeine.

Alkaloids derived from anthranilic acid.

Alkaloids derived from histidine.


Learning activities and methodology

Title Hours ECTS Learning outcomes
Lectures 30 1.2 KM03, KM04, SM02
Problem classes 10 0.4 KM03, SM02
problems resolution 102 4.08 KM03, SM02

In accordance with the course objectives, students will participate in a range of learning activities designed to help them achieve the intended knowledge and competencies. These activities are organized into three main categories.


Lectures

The lectures are intended to provide students with the fundamental concepts of the course. During these sessions, the instructor will present the core scientific content, which students are expected to complement through independent study, consultation of the recommended bibliography, and completion of the proposed learning activities.

Although lectures primarily constitute a one-way method of knowledge transfer from the instructor to the students, active participation will be encouraged through the discussion of case studies, questions, and other interactive classroom activities.

Throughout the semester, the instructor will also introduce and assign the exercises that students are expected to complete during the course.


Problem-Solving Sessions

A collection of exercises will be provided for students to work on throughout the semester. A selection of these exercises will be solved during the problem-solving sessions to demonstrate appropriate methodologies and problem-solving strategies.

These sessions will focus on discussing the solutions proposed by students based on their independent work, carried out either individually or in groups. Active participation will be encouraged, while the instructor will promote critical thinking and scientific reasoning to strengthen students' problem-solving abilities.


Continuous Assessment Activities

Throughout the course, students will complete a variety of learning and continuous assessment activities designed to reinforce and consolidate the concepts covered in class while fostering the development of the course learning outcomes and competencies.

These activities may include a wide range of tasks, such as exercises, quizzes, case studies, problem-solving activities, and both individual and group assignments. Whenever appropriate, innovative active-learning methodologies will be incorporated, including Challenge-Based Learning (CBL), the flipped classroom, gamification, and other student-centred teaching approaches.

Depending on the nature of the activity, these tasks may be carried out either inside or outside the classroom and must be submitted in the format and by the deadlines established by the instructor.

Completion and submission of all continuous assessment activities are mandatory and constitute an integral part of the course's continuous assessment.


Annotation: within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.

Assessment

Continuous assessment activities

Title Weight Hours ECTS Learning outcomes
Two partial exams 85% (35% + 50%) 5 0.2 KM03, KM04, SM02
Assignment submission 15% 3 0.12 KM03, KM04, SM02


Assessment is based on continuous assessment, which aims to monitor students' learning progress, encourage continuous engagement throughout the semester, and verify the achievement of the course learning outcomes.

Assessment is individual and consists of the following components:

  • Continuous assessment activities (15%): individual or group activities (such as exercises, quizzes, case studies, and other learning activities) designed to reinforce course content and develop the intended competencies.
  • First midterm examination (35%): covers approximately the first third of the course content. A minimum mark of 4.0/10 is required.
  • Second midterm examination (50%): covers the remainder of the course syllabus. A minimum mark of 4.0/10 is required.

To pass the course, students must obtain an overall final grade of at least 5.0/10 and a minimum mark of 4.0/10 in each midterm examination.

Students who do not pass the course, or who wish to improve their grade, may take the resit examination, which consists of two independent sections corresponding to the two midterm examinations. Students may resit either one or both sections.

To be eligible for the resit examination, students must have completed assessment activities accounting for at least 67% of the final course grade. Otherwise, they will receive a "Not Assessable" (NA) grade.

This course does not offer a single assessment option.


The use of artificial intelligence (AI) tools is permitted only as support for literature searches and information retrieval. Any use of AI in assessed activities must be explicitly acknowledged by identifying the tools used and describing their contribution to the work. Undeclared use of AI will be considered a breach of academic integrity and may result in a penalty in the assessment.

Any irregularity in an assessment activity (academic fraud, plagiarism, or unauthorized use of AI, unless such use is explicitly permitted in the course syllabus) that may lead to a significant alteration of the grade will result in a mark of 0 for that assessment. If the course syllabus establishes a minimum grade in that assessment as a mandatory requirement to pass the course, or if multiple irregularities are committed in assessment activities for the same course, the final grade for the course will be 0. In addition, disciplinary proceedings may be initiated against any student involved in such irregularities.

Bibliography


  • Medicinal natural products. A biosynthetic approach, P. M. Dewick, Wiley, 3rd edition, 2009. ISBN: 978-0-470-74168-9. As E-book: ISBN: 978-1-119-96457-5, 2011
  • Natural Products. Their Chemistry and Biological Significance. J. Mann, R. S. Davidson, J. B. Hobbs, D. V. Banthorphe and J. B. Harborne. Pearson Education Limited, 1994. ISBN 0-582-06009-5.

The material of the course will be found in the moodle space of the UAB virtual campus. In this material you will find: general information, transparencies used in class or support, exercises to deliver, reinforcement exercises (if deemed necessary), qualifications of the partial examinations and any other information that is considered of interest for the students.

Software

No specific software is required.

Course groups and languages

The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE

Type of teaching Group Language Semester Shift
(TE) Theory 34 Catalan first semester morning-mixed
(PAUL) Classroom practices 341 Catalan first semester morning-mixed