Important notice
The course guide is provisional.
The PDF version of the course guide may take a few days to become available in the DDD.

Biomoleculary Chemistry
Code: 42427Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Industrial Chemistry and Introduction to Chemical Research | OP | 1 |
Contact lecturer
- Name :
- Maria del Mar Puyol Bosch
- Email :
- mariadelmar.puyol@uab.cat
Teaching staff
- Manel del Valle Zafra
- Antonio Calvo Lopez
- Jean-Didier Pierre Marechal
- Xavier Ceto Alseda
- Oscar Palacios Bonilla
- Maria Isabel Pividori Gurgo
- Rosanna Rossi
Group languages
You can consult this information at the end of the document.
Prerequisites
The students involved in this module should have background in chemistry (Analytical Chemistry, Physical Chemistry, Inorganic Chemistry and Organic Chemistry), as well as knowledge in Mathematics, Physics and Biology. Students should also have skills in management of common office applications, possess the English knowledge necessary for understanding lectures, scientific texts, documents, seminars and conferences. Graduates in Chemistry, Chemical Engineering, Materials Science, Nanoscience, Environmental Sciences, Biotechnology, Biochemistry have enough background to take part of this module.
Advanced level of English (level B1) of the Common European Framework Reference for Languages of the European Council is required.
Objectives
The role of bioanalytical, bioorganic and bioinorganic chemistry in genomics, proteomics, metabolomics and medicine.
- Applying basic concepts of chemistry in biological systems in the field of human health, environmental control, food safety and biotechnology industry.
- Integrating bio recognition and biological reactions in chemical methodology.
- Handling the most common techniques in chemistry to analyze, separate, identify and synthesize compounds in a biological context.
- Applying this knowledge to solve daily problems.
Learning outcomes
- Students should know how to communicate their conclusions, knowledge and final reasoning that they hold in front of specialist and non-specialist audiences clearly and unambiguously
- Identify information in the scientific literature using the appropriate channels and integrating said information to approach and contextualise a research issue.
- Use scientific terminology in the English language to defend experimental results in the context of the chemistry profession.
- Correctly apply new information capture and organisation technologies to solve problems in professional activity.
- Possess and understand knowledge that provides a basis or opportunity for originality in the development and/or application of ideas, often in a research context
- Student should possess an ability to learn that enables them to continue studying in a manner which is largely self-supervised or independent
- Students should know how to apply the knowledge acquired and the capacity to solve problems in new or little-known areas within broader (or multidisciplinary) contexts realted to thier area of study
- Identify the contribution of Bimolecular Chemistry to medical and biomedical applications.
- Use modified biomolecules in bio-analysis.
- Recognize the structure of biomolecules and mimetic and relate it to their biological function
- Differentiate ligand-receptor interactions and relate specific biorecognition processes.
- Design synthesis strategies and recognize the properties of natural products.
- Applying general methods of analysis and characterization of biomolecules.
Contents
General content
• Structure, function and biorecognition of natural and recombinant biomolecules such as enzymes, antibodies, DNA, cell receptors, DNA/RNA, metal-containing biomolecules. Biomimetic.
• Molecules for medical diagnosis and therapy.
• Relationship of metals with biomolecules.
• Computational techniques in Biomolecular Chemistry. Relationship between chemical, biological and conformational space.
• Proteomics
• Production of biomolecules. Monoclonal and polyclonal antibodies. Recombinant proteins. Separation of biomolecules and labelling with nanomaterials. Bioanalysis. Immunoassays, PCR, catalytic biological methods.
• Biosensors, nanobiosensors and advanced sensing technologies. Integration of nanomaterials in rapid diagnostic tests (lateral flow, agglutination test, immunoassays, Lab-on-a-chip) for the diagnosis and monitoring of diseases.
Syllabus
Biomolecules and biomimetics. Structure, function and biorecognition. Contents: Proteins: enzymes, affinity proteins, antibodies, diabodies, affibodies, avimers, cell receptors. Biorecognition and function: enzyme/substrate; antigen/antibody; receptor/ligand interaction. Structure and function of DNA/RNA. Amplification. Molecular beacons. Aptamers. Molecularly imprinted polymers and plastic antibodies.
Biomolecules containing metals: structure, function and mimetics. Content: The biochemistry of metal ions. Capture, transport and storage of metal ions in biology. Electron transfer, respiration, and photosynthesis. Oxygen metabolism. Other metalloproteins of interest. Metal ion receivers and signaling. Metals in medicine.
Computational techniques in biomolecular chemistry. Content: General principles of molecular modeling. Specifics of computing at the chemistry–biology interface. Relationship between chemical, biological, and conformational space. Protein–ligand docking techniques. Molecular dynamics. Multiscale. Reactivity in biochemical systems. Examples. Advantages, limitations.
Proteomics: Contents: Principles of proteomics, types and preparation of samples, peptide separation techniques, mass spectrometry analyzers and ionization sources, bioinformatic analysis, examples of applications of proteomics protocols in biomedicine.
Biosensors and Biomolecular Chemistry. Contents: Definition, historical development and evolution. Components. Types of bioreceptors and transducers. Market trends and challenges, key sectors. Case studies of successful biosensors. Types of specialized biosensors.
Production, separation, modification and determination of biomolecules. Content: Isolation and production of biomolecules. The immune system: production of polyclonal and monoclonal antibodies. Separation strategies. Labelling with nanomaterials and immobilization of biomolecules in nanostructured materials. Bioanalysis: immunochemical methods, DNA analysis, PCR, biological catalytic methods, other biological catalysts: DNAzymes, biodetection. Chips and arrays.
Nanobiosensors and advanced sensing technologies : Role of nanomaterials in molecular recognition, nanostructured transducers (metal nanoparticles, carbon dots, quantum dots, carbon nanotubes, graphene). Biofunctionalization of surfaces and improvement of signals. Advanced biosensor technologies: nanomaterials and lab-on-a-chip, wearable and implantable biosensors. Artificial intelligence (AI) and data analytics in biosensing. Biosensors for personalized medicine.
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Preparation of oral presentation and papers | 40 | 1.6 | |
| Tutorials | 5 | 0.2 | |
| Problems | 8 | 0.32 | |
| Autonomous learning and studying | 49 | 1.96 | |
| Lectures | 30 | 1.2 |
Lectures
Problem-solving lectures
Cooperative activities
Seminars
Preparation and oral presentation of papers
Tutorials
For this course, the use of Artificial Intelligence (AI) technologies is permitted exclusively for support tasks, such as bibliographic or information searches, text correction, or translations. The student must clearly identify which parts were generated with this technology, specify the tools used, and include a critical reflection on how these have influenced the process and the final result of the activity. Failure to be transparent about the use of AI in this graded activity will be considered an act of academic dishonesty and may result in a partial or full penalty on the activity's grade, or more severe sanctions in more serious cases.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Oral defense of projects | 40 % | 6 | 0.24 | 1, 2, 8, 9, 10, 11, 12, 13 |
| Reports and problems | 30 % | 4 | 0.16 | 1, 4, 5, 6, 7, 9, 10, 11, 12, 13 |
| Writing assessment | 30 % | 8 | 0.32 | 3, 4, 6, 8, 9, 10, 11, 12, 13 |
The evaluation of this module will take into account the attendance and participation in class as well as the work and assessments presented by the students. All subjects are compulsory attendance. The different topics presented by each of the professors will be separately evaluated, by different assesments including writing exams, theoretical and practical tests, oral presentations, research papers discussion, in-class brief questions, written works, etc.
- Every professor decides the number and typology of evaluation activities: oral presentations, written exams, delivery of discussed articles, tests.
- The final mark of the module will be the sum of the marks of every professor multiplied by the percentage of his classes in the total teaching of the module.
- To pass a module, it is mandatory to have a mark of 3.5 or higher in 75% of all the activities in order to average with other marks of the professor and/or the module.
- There will be a period in January to repeat written exams with marks under 5. In the case of exams under 3,5, it will be mandatory to the student. In the case of exams between 3,5 and 5 it would be optional.
- The marks of other evaluations activities (i. e. oral presentations) will average with the rest of the marks of the professor/module independently of the value. There will be not option of repeating these evaluation activities.
VERY IMPORTANT: Partial or total plagiarising will immediately result in a FAIL (0) for the plagiarised exercise and the WHOLE subject. PLAGIARISING consists of copying text from unacknowledged sources -whether this is part of a sentence or a whole text - with the intention of passing it off as the student's own production. It includes cutting and pasting from internet sources, presented unmodified in the student's own text. Plagiarising is a SERIOUS OFFENCE. Students must respect authors' intellectual property, always identifying the sources they may use; they must also be responsible for the originality and authenticity of their own texts.
In the event of a student committing any irregularity that may lead to a significant variation in the grade awarded to an assessment activity, the student will be given a zero for this activity, regardless of any disciplinary process that may take place. In the event of several irregularities in assessment activities of the same subject, the student will be given a zero as the final grade for this subject.
The commission of any irregularity in an assessment (academic fraud, plagiarism, or improper use of AI, unless such use is expressly authorized in the course syllabus), which could lead to a significant change in the grade, will result in that assessment being graded 0. If the course guide stipulates that obtaining a minimum score on this assessment is a mandatory requirement to pass the course, or if multiple irregularities occur in the assessments for the same course, the final grade for that course will be 0. In addition, disciplinary proceedings may be initiated against any student who commits any of these irregularities.
Bibliography
Química Bioinorgánica, J. S. Casas, V. Moreno, A. Sánchez, J. L. Sánchez, J. Sordo, Editorial Síntesis, Colección Biblioteca de Químicas, 2002
Bioanalytical Chemistry, S. Mikkelsen, E. Corton, Wiley, 2004
Molecular Modelling Principles and Applications - Second Edition -Andrew R. Leach - Ed: Prentice Hall 2001
Bibliografia addicional
Inorganic Chemistry in Biology,P. C. Wilkins, R. G. Wilkins, Oxford Chemistry Primers, n. 46, Oxford University Press, 1997
Principles of Bioinorganic Chemistry, S. J. Lippard, J.M. Berg, University Science Books, 1994
Principles and Practice of Bioanalysis, R. F.Venn, (Editor), Taylor & Francis, 2000.
Bioanalytical Chemistry, A. Manz, N. Pamme, D. Iossifidis, Imperial College Press, 2004.
Principles of Chemical and Biological Sensors, D. Diamond (Editor), Wiley, 1998.
Biosensors, Elizabeth A. H. Hall, Open Univ Press, 1991
Software
ChemDraw
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TEm) Theory (master) | 1 | English | first semester | morning-mixed |