
Molecular Anthropology
Code: 100752Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Biology | OP | 4 |
Contact lecturer
- Name :
- Cristina Maria Pereira Dos Santos
- Email :
- cristina.santos@uab.cat
Teaching staff
- Daniel Ruiz de la Cuesta Aguirre
Group languages
You can consult this information at the end of the document.
Prerequisites
Objectives
The course of Molecular Anthropology is integrated in the field of Human Biology. It is a relatively new field of research, in fact, there have been less than 50 years since Emil Zuckerkandl, in the symposium "Classification and Human Evolution" (1962, Wartenstein Burg, Austria), formally introduced the designation. As the name suggests, Molecular Anthropology, focuses on the study of human evolution and variation using molecular tools.
The main objective of this course is to deepen in the study of the tools and methods used in the study of variation and evolution of humans. In this regard, it stresses the Human Genome Diversity Project as a turning point for Molecular Anthropology since it has played a key role in changing perspective of Molecular Anthropology from genetics to genomics. The most recent projects to analyze human variation, the 1000 Genomes and HapMap, will be discussed. The problems of the study of human genetic variation in both recent and ancient remains will be explored. Also, the genetic variation as a tool to reconstruct the evolutionary history and for mapping disease susceptibility variants and with pharmacogenomic interest will be approached.
Learning outcomes
- Be able to analyse and synthesise.
- Work in teams.
- Apply statistical and computer resources to the interpretation of data.
- Be able to organise and plan.
- Students must have and understand knowledge of an area of study built on the basis of general secondary education, and while it relies on some advanced textbooks it also includes some aspects coming from the forefront of its field of study.
- Students must be capable of applying their knowledge to their work or vocation in a professional way and they should have building arguments and problem resolution skills within their area of study.
- Students must be capable of collecting and interpreting relevant data (usually within their area of study) in order to make statements that reflect social, scientific or ethical relevant issues.
- Students must be capable of communicating information, ideas, problems and solutions to both specialised and non-specialised audiences.
- Students must develop the necessary learning skills to undertake further training with a high degree of autonomy.
- Analyse a situation and identify its points for improvement.
- Propose new methods or well-founded alternative solutions.
- Critically analyse the principles, values and procedures that govern the exercise of the profession.
- Analyse the sex- or gender-based inequalities and the gender biases present in one's own area of knowledge.
- Propose projects and actions that incorporate the gender perspective.
- Interpret human variability as a source of individualisation.
- Interpret values of human demography and epidemiology.
- Identify the biological characteristics of human nature at all levels of organisation.
- Analyse present and past intra-population and inter-population variability in our species.
- Manipulate human samples and perform morphological, molecular and chromosome determinations for the diagnosis and prevention of diseases.
- Analyse the sustainability indicators of the academic and professional activities within the area, integrating the social, economic and environmental dimensions.
- Propose ways to evaluate projects and actions for improving sustainability.
Contents
THEORY:
Unit 1. Foundations of molecular anthropology: from morphology to the HapMap Project and the 1000 genomes project
Unit 2. Tools and Methods in Molecular Anthropology
Unit 3. Genetic variations in humans and other primates: Diversity, phylogeography and selection
Unit 4. Quantitative Genetics: applications in molecular anthropology
Unit 5. Confluence of molecular anthropology and epidemiology
Unit 6. Ancient DNA: problems and applications
Unit 7. Application of molecular anthropology in forensic sciences
SEMINARS:
Presentation of group work
COMPUTER PRACTICES:
HapMap Project and the 1000 Genomes Project
Tools and Methods in Molecular Anthropology
Applications in Genetic Epidemiology
LAB PRACTICES:
DNA extraction and PCR
Detection of SNPs
NGS DNA sequencing
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Group work: Research project proposal | 40 | 1.6 | 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 20, 21 |
| Laboratory Practices | 10 | 0.4 | 1, 2, 3, 4, 15, 17, 18, 19 |
| Tutorship (individual or group) | 4 | 0.16 | |
| Preparation of seminars and internships | 6 | 0.24 | 1, 2, 3, 17, 18 |
| Computer practices | 8 | 0.32 | 1, 3, 15, 17, 18 |
| Individual Study | 30 | 1.2 | 1, 2, 4, 5, 6, 7, 8, 9, 15, 16, 17, 18, 19 |
| Practice report | 20 | 0.8 | 1, 3, 4, 15, 18, 19 |
| Theory classes | 28 | 1.12 | 1, 2, 4, 6, 7, 8, 9, 10, 13, 15, 16, 17, 18 |
| Seminars | 4 | 0.16 | 1, 2, 3, 4, 5, 6, 7, 8, 9, 16, 17, 18 |
The development of the training activities of the course is based on: theory classes, seminars, classroom practices and laboratory and computer practices, each of them with its specific methodology. Likewise, a series of activities are proposed that will allow the student to take an active role in the teaching-learning process.
Classes of theory: The student acquires the scientific knowledge of the subject by attending theory classes. These are classes with TIC-TAC support in which the teacher exposes the subject but also asks for the participation of the student. Likewise, activities are proposed that allow the student to intervene more actively in the teaching-learning process. In this sense, some theoretical sessions are devoted to topics related to group work carried out by students, both for the resolution of doubts and the presentation of key concepts, as well as for the presentation of the work itself. The audiovisual material used in class can be found by the student in the Moodle space of the subject.
Seminars: Specialists are invited and in advance the student will be provided with the topics to be debated in the seminar; students will have to prepare the seminars collaboratively with their classmates and present the group work done.
Classes of practices: The knowledge acquired in theory classes and in personal study are applied to the resolution of practical cases. Students work in small groups allowing them to acquire the ability to work in groups and analysis and synthesis. It also allows to apply lab and statistical resources in the interpretation of data. The student can access the practice guides through the Moodle space
The work of the subject (both digital support and oral presentation) can be done in Catalan, Spanish or English.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Practical materials | 25% | 0 | 0 | 5, 6, 7, 8, 9, 19 |
| Critical summary of a group work | 10% | 0 | 0 | 1, 2, 10, 19 |
| Exam | 35% | 0 | 0 | 1, 4, 15, 16 |
| Preparation, presentation and defense of group work (research project proposal) | 30% | 0 | 0 | 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 20, 21 |
Continuous assessment
For the evaluation of the subject, a continuous assessment model will be followed. The participation of the student, the preparation and presentation of the group work (research project proposal), the practical materials, the critical summary of a group work and the exam rate will be taken into account, in the following proportions:
Exam: 35%
Group work (research project proposal): 30%
Critical summary of a group work: 10%
Training materials: 25%
In the development of all the activities, including those of the theoretical typology, the student will be asked to previously prepare some concepts, and in the case of the group work, the whole process of elaboration during the semester will be taken into account.
Group work (both digital support and oral presentation and defense) can be done in Catalan, Spanish or English.
There will be an integrative examination of the contents of the subject that students must overcome with a minimum of 4.
Recovery: in the case of necessity, the note of the group work and the integrative examination can be recovered. To participate in the recovery, students must have been previously evaluated in a set of activities the weight of which equals a minimum of two thirds of the total grade of the subject. Therefore, the students will obtain the \"Not Evaluable\" qualification when the evaluation activities carried out have a weight lower than 67% in the final grade.
The grade of the summary evaluation can be raised, in this case, the classification that will be considered will bethe last one, regardless of whether it is superior or inferior to that obtained previously.
The weighted average mark of the different evaluable parts (Participationof the student in the face-to-face and virtual learning activities, Practical materials, Group work, Critical summary of a group work, Examination) must be equal to or greater than 5.0.
Single assessment
This subject provides for the single assessment system, with attendance at practicals and seminars being compulsory. In this sense, the unique assessment consists of carrying out the following activities:
1) Written test that includes the entire program of the subject. This test will consist of test-type and written questions, in which the resolution of some problems is included. This test represents 50% of the final grade and a minimum grade of 4 is required to pass the subject. It will take place on the day of the summative assessment of the subject.
2) Research project proposal: in the case of a single assessment, the research project proposal will be developed individually and periodic submissions are not required. During the course of the semester, students who take single assessment will be able to set up tutorials with the teaching staff if they need it. The final delivery of the project in written format will be made on the same day that the summative assessment of the subject is scheduled. This activity represents 30% of the subject grade.
3) Practice materials: it is carried out individually following the same instructions as presented in the continuous assessment section. It will be handed in on the same day that the summative assessment of the subject is scheduled and represents 20% of the grade of the subject.
Recovery: in case of need, the grade of the written test can be recovered,on the same day as the recovery exam for the subject is scheduled.
Artificial Intelligence:
For this subject, the use of Artificial Intelligence (AI) technologies is permitted exclusively in support tasks, such as bibliographic or information searches, text correction or translations, or others at the discretion of the teaching staff. The student must clearly identify which parts have been generated with this technology, specify the tools used and include a critical reflection on how these have influenced the process and the final result of the activity. The lack of transparency in the use of AI in this evaluable activity will be considered a lack of academic honesty and may lead to a partial or total penalty in the grade of the activity, or greater sanctions in serious cases.
Irregularities in Assessment Activities
Any irregularity committed during an assessment activity (academic fraud, plagiarism, or improper use of Artificial Intelligence, unless such use is expressly authorized in the course syllabus) that may lead to a significant alteration of the assessment result will result in a grade of 0 for that activity. If the course syllabus establishes that obtaining a minimum grade in that assessment activity is an essential requirement to pass the course, or if multiple irregularities occur in the assessment activities of the same course, the final grade for the course will be 0. Furthermore, disciplinary proceedings may be initiated against any student who commits any of these irregularities.
Bibliography
Basic bibliography:
Crawford MH. 2007. Anthropological Genetics: Theory, Methods and Applications. Cambridge University Press. (http://eds.b.ebscohost.com/eds/detail/detail?vid=0&sid=e31c3e2b-9132-47be-8a0c-72002e84078e%40pdc-v-sessmgr02&bdata=JnNpdGU9ZWRzLWxpdmU%3d#AN=206816&db=nlebk)
Destro-Bisol G. 2010. Molecular Anthropology in the Genomic Era. Journal of Anthropological Sciences, 88:93-112 (http://www.isita-org.com/jass/Contents/2010vol88/PDFonline/20834052.pdf)
Relethford J. 2013. The Human Species: An Introduction to Biological Anthropology. 9th Edition. McGraw-Hill.
Stoneking, M. 2016. An Introduction to Molecular Anthropology. John Wiley & Sons, Incorporated (https://ebookcentral.proquest.com/lib/UAB/reader.action?docID=4719165&ppg=185)
Specific bibliography, Webs and Videos:
It will be given during the course.
Software
-Jamovi Stats. Open. Now. (https://www.jamovi.org/)
-HaploView (https://www.broadinstitute.org/haploview/haploview)
-BioEdit (https://www.nucleics.com/DNA_sequencing_support/Trace_viewer_reviews/BioEdit/)
-Arlequin (http://cmpg.unibe.ch/software/arlequin35/)
-Network (https://www.fluxus-engineering.com/sharenet.htm)
-Neighbor (Phylip) (https://evolution.gs.washington.edu/phylip/doc/neighbor.html)
-R-Studio
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TE) Theory | 14 | Spanish | second semester | morning-mixed |
| (PLAB) Practical laboratories | 141 | Spanish | second semester | afternoon |
| (SEM) Seminars | 141 | Spanish | second semester | morning-mixed |