Important notice
The course guide is provisional.
The PDF version of the course guide may take a few days to become available in the DDD.

Applied Biocatalysis and Biotransformations
Code: 43332Credits: 9
| Degree programme | Type | Course |
|---|---|---|
| Biological and Environmental Engineering | OB | 1 |
Contact lecturer
- Name :
- Oscar Romero Ormazabal
- Email :
- oscar.romero.ormazabal@uab.cat
Teaching staff
- Marina Guillen Montalban
- Oscar Romero Ormazabal
Group languages
You can consult this information at the end of the document.
Prerequisites
Basic knowledge of:
- Protein structure
- Biochemistry
- Catalysis
- Kinetic enzyme
- Microbial growth
- Cell biology
- Chemical Engineering principles
Objectives
The objective is to present biocatalysis and its fields of application as an alternative to classical catalysis. The knowledge of biocatalysts will be deepened as the central axis of a transformation and of the aspects of engineering of the main elements that make up biotransformation, such as the biocatalyst, the reaction medium, the bioreactor and its operation. Moreover, the classification and study of different biotransformations according to the biocatalyst used will be analyzed in different case studies. The final objective is to be able to define the main elements of a biotransformation and to design a biocatalytic process.
Learning outcomes
- CA21 (Design a biocatalytic process for its industrial application, integrating the state of the art of biocatalysis, its fields of application and the different relevant types of biotransformation.) Design a biocatalytic process for its industrial application, integrating the state of the art of biocatalysis, its fields of application and the different relevant types of biotransformation.
- CA22 (Summarise and interpret, in a logical and reasoned manner, information from biodegradability or molecular biology studies.) Summarise and interpret, in a logical and reasoned manner, information from biodegradability or molecular biology studies.
- KA18 (Distinguish between the fundamental concepts of Chemical Engineering in the different forms of reactor design and operation, including catalytic reactors and with special emphasis on reactors with immobilised biological catalysts.) Distinguish between the fundamental concepts of Chemical Engineering in the different forms of reactor design and operation, including catalytic reactors and with special emphasis on reactors with immobilised biological catalysts.
- KA19 (Distinguish the different reaction media used in biotransformations and select the appropriate reaction media.) Distinguish the different reaction media used in biotransformations and select the appropriate reaction media.
- KA20 (Distinguish the methods for immobilising biocatalysts and for characterising the immobilised biocatalyst.) Distinguish the methods for immobilising biocatalysts and for characterising the immobilised biocatalyst.
- KA21 (Identify multienzymatic processes.) Identify multienzymatic processes.
- SA23 (Calculate the main elements involved in biotransformation, such as the biocatalyst, the reaction medium, the bioreactor and its operation.) Calculate the main elements involved in biotransformation, such as the biocatalyst, the reaction medium, the bioreactor and its operation.
Contents
Assignment program:
- Topic 1 Introduction to biocatalysis
- Topic 2 Biocatalysts
- Topic 3 Biocatalyst engineering
- Topic 4 Reaction medium engineering
- Topic 5 Bioreactor operation
- Topic 6 Biotransformations: case studies
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Individual study | 127 | 5.08 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
| Carry out work on a case study | 20 | 0.8 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
| Theoretical classes | 49 | 1.96 | KA18, KA19, KA20, KA21 |
| Seminars and case studies | 6 | 0.24 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
| Search for documentation and bibliography | 20 | 0.8 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
Directed activities:
- Theoretical lectures: Master classes on the concepts of the subject
- Seminars: Presentation to students of different cases of study of biotransformations and applied biocatalysis extracted from the bibliography
- Public presentation of the work: Students will orally and publicly present a summary of the most relevant results of the work and deliver the presentation to the professor in digital format through the virtual campus
Communication with Students
Communication with students will take place via the Moodle Classroom on the Virtual Campus.
Autonomous activities:
- Individual study: Individual study, preparation of diagrams and summaries.
- Documentation and bibliography search: Consultation of the bibliographic and documentary sources essential for the course.
- Realization of a work: work in groups of 2-4 students in which each group will elaborate a written work on a case study previously selected by the teacher. The work will be delivered to the teacher in paper format (printed) and in digital format through the virtual campus, in order to discuss in seminars and written presentation.
Informative Note:
The use of AI is permitted to improve the drafting and style of the reports. However, generating original content with AI is strictly prohibited. If AI tools are used, their use must be explicitly declared, and it must be clearly identified within what they were used for.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Oral and public presentation of the work | 10% | 1 | 0.04 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
| Partial exam (topics 4, 5 and 6) | 35% | 1 | 0.04 | CA21, KA18, KA19, KA20, KA21, SA23 |
| Partial exam (themes 1, 2 and 3) | 35% | 1 | 0.04 | KA18, KA20, KA21 |
| Written work | 20% | 0 | 0 | CA21, CA22, KA18, KA19, KA20, KA21, SA23 |
Scheduled evaluation process and activities
Throughout the course different evaluation activities will be carried out that will lead to the final grade of the subject obtained by continuous evaluation. Specifically, the evaluable activities will be:
- Written work in groups on a case study that is 20% of the final grade.
- Oral and public presentation of the written work that is 10% of the final grade
- Attendance at all oral presentations is compulsory for all students
- Partial exam of topics 1, 2 and 3, which represents 35% of the final grade
- Partial examination of topics 3, 4 and 5, which represents 35% of the final grade
The written work and the oral presentation of the assignment are not eligible for resit.
The course is considered passed if the average of the 4 activities is 5 or higher. To calculate the average, each activity must have a grade of 4 or above.
If the average of the 4 activities is below 5, or any of the components has a grade below 4, the failed activities (those with less than 5) must be retaken, except for the assignment and the oral presentation, which cannot be resubmitted.
Any of the following circumstances will result in a grade of \"Not assessable\" for the course:
- Not submitting the written assignment
- Not doing the oral presentation of the assignment
- Not taking one of the exams
Programming evaluation activities
At the beginning of the subject groups will be formed to do the written work. The delivery of written work and oral presentations will be communicated through the virtual campus.
Recovery process
The student can apply for recovery whenever he has submitted to a set of activities that represent at least two thirds of the total grade of the subject. Of these, students who have on average of all the activities of the subject a grade higher than 3.5 may be presented in the recovery.
The partial exams are eliminatory, therefore, a student who has passed a partial exam will not be able toappear forthe recovery of this exam. Youwill have to compulsorily recover those partial exams where the student has obtained a grade lower than 4 regardless of the average obtained according to the calculation of the section \"Process and programmed evaluation activities\"
The calculation of the grade will be done in the same way as in the continuous evaluation
Procedure for review of qualifications
For each evaluation activity, a place, date and time of revision in which the student can review the activity with the teacher will be indicated. In this context, claims may be made on the activity grade, which will be evaluated by the faculty responsible for the subject. If the student does not appear in this review, this activity will not be reviewed later.
Ratings
Granting a grade of honor registration is the decision of the faculty responsible for the subject. The regulations of the UAB indicate that MH can only be granted to students who have obtained a final grade equal to or greater than 9.00. You can grant up to 5% of MH of the total number of students enrolled.
Irregularities by the student, copy and plagiarism
Without prejudice to other disciplinary measures deemed appropriate, the irregularities committed by the student that may lead to a variation of the grade of an evaluation act will be scored with a zero. Therefore, copying, plagiarism, cheating,letting copy, etc. in any of the evaluation activities will involve suspending with a zero. The evaluation activities qualified in this way and by this procedure will not be recoverable. If it is necessary to pass any of these evaluation activities to pass the subject, this subject will be suspended directly, without the opportunity to recover it in the same course. In this situation the final grade that will be reflected in the minutes will be a 2.
Evaluation of repeating students
There is no provision for a different evaluation system for repeating students.
Unique Assessment
This subject does not offer single assessment.
Bibliography
Books:
Immobilized Biocatalysts
Peter Grunwald (Ed.)
Pages: 510
Published: November 2018
ISBN 978-3-03897-318-8 (Pbk); ISBN 978-3-03897-319-5 (PDF)
https://doi.org/10.3390/books978-3-03897-319-5
© 2018 by the authors; CC BY-NC-ND licenes
https://www.mdpi.com/books/pdfview/book/861
Biocatalysis for Green Chemistry and Chemical Process Development
Editor(s): Junhua (Alex) Tao, Romas Kazlauskas
First published:12 April 2011
Print ISBN:9780470437780 |Online ISBN:9781118028308 |DOI:10.1002/9781118028308
Copyright © 2011 John Wiley & Sons, Inc.
https://onlinelibrary-wiley-com.are.uab.cat/doi/book/10.1002/9781118028308
Carrier‐bound Immobilized Enzymes: Principles, Application and Design
Author(s): Dr. Linqiu Cao
First published:29 September 2005
Print ISBN:9783527312320 |Online ISBN:9783527607662 |DOI:10.1002/3527607668
Copyright © 2005 Wiley‐VCH Verlag GmbH & Co. KGaA
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991010341558406709
Green Biocatalysis
Editor(s): Ramesh N. Patel
First published:13 May 2016
Print ISBN:9781118822296 |Online ISBN:9781118828083 |DOI:10.1002/9781118828083
Copyright © 2016 John Wiley & Sons, Inc.
https://cataleg.uab.cat/iii/encore/record/C__Rb2087415?lang=cat
Autor | |
Títol | Enzyme structure and mechanism / Alan Fersht |
Edició | 2nd. ed. |
Publicació/producció | New York : W.H. Freeman, cop. 1985 |
Descripció | xxi, 475 p.; 24 cm |
Matèria | |
ISBN | 0716716143 |
0716716151 (pbk.) |
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991002478739706709
Autor | |
Títol | Enzymes / by Malcolm Dixon and Edwin C. Webb |
Edició | 3rd ed. |
Publicació/producció | London : Longman, 1979 |
Descripció | XXIII + 1116 p.; 24 cm |
Matèria |
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991000758989706709
Títol | Enzyme biocatalysis : principles and applications / Andrés Illanes, editor |
Publicació/producció | [Dordrecht] : Springer, 2008 |
Descripció | X, 391 p. : ill. ; 25 cm. |
Matèria | |
ISBN | 9781402083600 |
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991008142159706709
Títol | Ingeniería bioquímica/ Francesc Gòdia Casablancas y Josep López Santín (editores) ; Carles Casas Alvero ... [et al.] |
Publicació/producció | Madrid : Síntesis, DL 1998 |
Descripció | 350 p. : il.; 24 cm |
Col·lecció | Ciencias químicas (Síntesis). Tecnología bioquímica y de los alimentos |
Matèria | |
ISBN | 8477386110 |
http://cataleg.uab.cat/record=b1425826~S1*cat
Autor | |
Títol | Biocatalysis : [fundamentals and applications] / A.S.Bommarius, B.R.Riebel |
Publicació/producció | Weinheim : Wiley-VCH, 2004 |
Descripció | XXIII, 611 p.; 24 cm |
Matèria | |
ISBN | 3527303448 |
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991010349685006709
Títol | Multi-step enzyme catalysis : biotransformations and chemoenzymatic synthesis / edited by Eduardo Garcia-Junceda |
Publicació/producció | Weinheim : Wiley-VCH ; Chichester : John Wiley, 2008 |
Descripció | 241 p. ; 25 cm |
Matèria | |
ISBN | 9783527319213 |
http://cataleg.uab.cat/record=b1747444~S1*cat
Títol | Immobilization of enzymes and cells / edited by Gordon F. Bickerstaff |
Publicació/producció | Totowa : Humana Press, 1997 |
Descripció | XIV, 367 p.;23 cm |
Col·lecció | |
Matèria | |
ISBN | 0896033864 |
https://bibcercador.uab.cat/permalink/34CSUC_UAB/cugbhl/alma991010401253806709
Autor | |
Títol | Biotransformations in organic chemistry : a textbook : with 37 figures, 238 schemes and 16 tables / Kurt Faber |
Edició | 5th revised and corrected ed. |
Publicació/producció | Berlin: Springer-Verlag, cop. 2004 |
Descripció | XI, 453 p. : il; 24 cm |
Matèria | |
ISBN | 3540200975 |
http://cataleg.uab.cat/record=b1615815~S1*cat
Autor | |
Títol | Biocatalysis : biochemical fundamentals and applications / Peter Grunwald |
Publicació/producció | London : Imperial College Press, 2009 |
Descripció | xvi, 1035 p. : il. ; 24 cm |
Matèria | |
ISBN | 9781860947711 |
1860947719 |
https://cataleg.uab.cat/record=b1778458~S1*cat
Kourist, R. (2015), Biocatalysis in Organic Synthesis. Science of Synthesis, Vol. 1–3. Edited by Kurt Faber, Wolf-Dieter Fessner and Nicholas J. Turner.. Angew. Chem. Int. Ed., 54: 12547. doi:10.1002/anie.201508130
Search engines of scientific bibliography:
Scholar Google: http://scholar.google.es/advanced_scholar_search?hl=en&lr=
Scopus: http://www.scopus.com/scopus/search/form.url?display=authorLookup
Scifinder: Software disponible a la UAB
Sience Direct: http://www.sciencedirect.com/science/journals
ISI Web of Knowledge: http://www.accesowok.fecyt.es/login/
Interesting web sites:
Base de dades d’enzims BRENDA: http://www.brenda-enzymes.info/
National Center for Biotechnology Information: http://www.ncbi.nlm.nih.gov/
ExPASy (Expert Protein Analysis System) Proteomic Server: http://www.expasy.ch/
Software
No software
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE