Important notice
The course guide is provisional.
The PDF version of the course guide may take a few days to become available in the DDD.
Advances in Clinical Biochemistry and Molecular Pathology
Code: 42886Credits: 9
| Degree programme | Type | Course |
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| Biochemistry, Molecular Biology and Biomedicine | OP | 1 |
Contact lecturer
- Name :
- Francisco Blanco Vaca
- Email :
- francisco.blanco@uab.cat
Teaching staff
- Roser Ferrer Costa
- Mireia Tondo Colomer
Teaching staff (external to UAB)
- Edgar Zapico Muñiz
- Alvaro García Osuna
- José Luis Sánchez Quesada
- José Manuel Soria Fernandez
- Francisco Illana Cámara
- Madalina Nicoleta Nan
- Noemi Rotllan Vila
- Leonor Guiñón
- Joan Carles Escolà Gil
Group languages
You can consult this information at the end of the document.
Prerequisites
Objectives
The main objective of the module is reviewing the progress recently made by the specialiality of Clinical Biochemistry and Molecular Pathology. It is intended, therefore, that students visualize this using examples, that are not intended to be exhaustive. The goal is that they understand how some applications in this area of Laboratory Medicine were generated and applied. The contents will be selected among those advances which, although recent, have proven of practical importance. The theoretical instruction is supplemented by expert seminars, discussion of articles and resolution of clinical cases.
Learning outcomes
- CA20 (Devise projects associated with the emerging challenges for clinical biochemistry and molecular pathology in industry and medicine.) Devise projects associated with the emerging challenges for clinical biochemistry and molecular pathology in industry and medicine.
- CA21 (Work as a team to address and solve problems and case studies associated with emerging challenges in clinical biochemistry and molecular pathology.) Work as a team to address and solve problems and case studies associated with emerging challenges in clinical biochemistry and molecular pathology.
- KA28 (Identify advances in molecular biology techniques for application in the clinical laboratory and in the biochemical diagnosis of cardiovascular diseases in emergency contexts.) Identify advances in molecular biology techniques for application in the clinical laboratory and in the biochemical diagnosis of cardiovascular diseases in emergency contexts.
- KA29 (Enumerate advances in the biochemical study of renal function in lipoprotein metabolism, dyslipidemia and arteriosclerosis.) Enumerate advances in the biochemical study of renal function in lipoprotein metabolism, dyslipidemia and arteriosclerosis.
- KA30 (Identify current issues in molecular biology research within the fields of clinical biochemistry and molecular pathology.) Identify current issues in molecular biology research within the fields of clinical biochemistry and molecular pathology.
- SA28 (Relate scientific and technological knowledge acquired in the fields of clinical biochemistry to molecular pathology.) Relate scientific and technological knowledge acquired in the fields of clinical biochemistry to molecular pathology.
- SA29 (Correctly apply the biochemical and genetic analyses that are performed in clinical laboratories based on their characteristics and special requirements.) Correctly apply the biochemical and genetic analyses that are performed in clinical laboratories based on their characteristics and special requirements.
Contents
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| MÓDULO 9 | Avances en Bioquímica Clínica y Patología Molecular |
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UNITAT DOCENT SANT PAU | |
| lunes | Presentación módulo. Salidas académicas y profesionales en Bioquímica Clínica y Patología Molecular | F. Blanco | 26-oct |
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| miércoles | CALIDAD EN EL LABORATORIO CLÍNICO (tema 1) | L.Guiñón | 28-oct |
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| viernes | SEMINARIOS I-II. Modelos animales de arteriosclerosis /MicroRNAs en investigación cardiovascular | J.C. Escolà / N. Rotllan | 30-oct |
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| lunes | MARCADORES BIOQUÍMICOS DE PATOLOGÍA CARDÍACA (tema 2). Diagnóstico bioquímico de infarto agudo de miocardio e insuficiencia cardíaca | A. García | 2-nov |
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| miércoles | SEMINARIO III- Biología molecular y celular de la arteriosclerosis / Cribaje familiar de la diabetes tipo 1 (comentario trabajo sobre artículo científico | J.L. Sánchez / F. Blanco | 4-nov |
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| viernes | MARCADORES BIOQUÍMICOS DE DAÑO METABÓLICO O VASCULAR (tema 3): Bioquímica clínica de la corteza suprarrenal | R. Ferrer | 6-nov |
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| lunes | Avances en lípidos y lipoproteínas (I). | F. Blanco | 9-nov |
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| miércoles | Avances en la medida del filtrado glomerular. Avances en lípidos y lipoproteínas (II) | E. Zapico / F. Blanco | 11-nov |
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| viernes | Predicción bioquímica de la preeclampsia. Preguntas relativas a temas 1, 2 y 3, y seminarios I-II | M.N. Nan/ F. Blanco | 13-nov |
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| lunes | ERRORES CONGÉNITOS DEL METABOLISMO (tema 4) | M. Tondo | 16-nov |
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| miércoles | SEMINARI III. Espectrometría de masas: bases y aplicaciones clínicas | E. Zapico | 18-nov |
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| viernes | CRIBADO PRENATAL (tema 5). | M.N. Nan | 20-nov |
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| lunes | ONCOLOGÍA (tema 6): Diagnóstico cáncer hereditario / Detección ADN libre tumoral | F. IIlana | 23-nov |
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| miércoles | Avances en marcadores tumorales. Discusión de casos clínicos y/o publicaciones, preguntas sobre temas 4, 5 y 6 | F.Illana | 25-nov |
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| viernes | DIAGNÓSTICO BIOQUIMICO DE ENFERMEDAD DE ALZHEIMER Y OTRAS ENFERMEDADES NEUROLÓGICAS (tema 7) | M. Tondo | 27-nov |
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| lunes | Presentación de publicaciones o casos clínicos por parte del alumnado | F. Blanco / M. Tondo | 30-nov |
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| miércoles | Presentación de publicaciones o casos clínicos por parte del alumnado | F. Blanco / M. Tondo | 2-des |
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| miércoles | CONFERENCIA CLAUSURA: Bases moleculares de las enfermedades complejas | J. Soria | 9-des |
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| Horario clases: 16:00-18.00 h. |
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| Teléfono contacto: Francisco Blanco 93-5537377 |
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| e-mail: fblancova@santpau.cat; francisco.blanco@uab.cat |
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| Lugar: Unitat Docent Sant Pau situado en el recinto del Hospital de Sant Pau, Barcelona. Paradas de metro cercanas en líneas azul y (especialmente) amarilla. |
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Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Study of clinical cases and reading scientific papers for class discussion: 67.5 h | 67.5 | 2.7 | |
| theoretical lessons, seminars, aula practicum: 45 h | 22.5 | 0.9 | |
| theoretical lessons, seminars, aula practicum: 45 h | 15 | 0.6 | |
| theoretical lessons, seminars, aula practicum: 45 h | 7.5 | 0.3 | |
| Study: 106.5 h | 106.5 | 4.26 |
Methodology includes autonomous activities (studying: 106.5 h), supervised activities (study of clinical cases and reading scientific papers for class discussion: 67.5 h) and directed activities (theoretical lessons, seminars, aula practicum: 45 h).
This module allows the use of Artificial Intelligence (AI) technologies as an integral part of the development of the work, provided that the final result reflects a significant contribution by the student in the analysis and personal reflection. The student must clearly identify which parts have been generated with this technology, specify the tools used and include a critical reflection on how these have influenced the process and the final result of the activity. The lack of transparency in the use of AI will be considered a lack of academic honesty and may lead to a penalty in the grade.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Attendance and active participation in classes | 30% | 0 | 0 | CA20, CA21, KA28, KA29, KA30, SA28, SA29 |
| Oral presentation of projects or clinical cases | 40% | 4 | 0.16 | CA20, CA21, KA28, KA29, KA30, SA28, SA29 |
| Presentation of homework and reports, small exams of short questions (in writing) | 30% | 2 | 0.08 | CA20, CA21, KA28, KA29, KA30, SA28, SA29 |
Unique evaluation will not be applied.
The continous evaluation process must include a minimum of three evaluation activities, of two different types, distributed throughout the course, none of which can represent more than 50% of the final grade
The evaluation will be based on: oral presentation of projects or clinical cases analysis (40% of the grade), presentation of small works and reports, as well as the answer to short exams (30% of the grade) and attendance to class and active participation (30 % of the grade)
Students who do not perform both theoretical and practical tests will be considered as \"not presented\", therrefore exhausting the rights of the registration.
If plagiarism is detected in any of the works delivered, this may mean that the student suspends the entire module or subject.
PROOF OF RECOVERY AND QUALIFICATION OF NOT EVALUABLE
To participate in exam recovery, students must have been previously evaluated in a set of activities, whose weight equals a minimum of 2/3 parts of the total grade of the subject or module. Therefore, the students will obtain a \"Not Evaluable\" qualification when the evaluation activities carried out have a weight lower than 67% of the final grade.
Bibliography
TEXTBOOKS:
1) Tietz texbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE eds. Elsevier, 2014.
2) Molecular Basis of Inherited Disease. Valle, Beaudet, Vogelstein et al. Saunders 2001 (digital edition with timely actualization: https://ommbid.mhmedical.com/ommbid-index.aspx).
SCIENTIFIC JOURNALS (Some of these journals allow public or limited access through intenet, or through the UAB website*):
1) Clinical Chemistry. http://search.ebscohost.com/direct.asp?db=ccm&jid=%2210CS%22&scope=site
2) Clinica Chimica Acta, https://www.sciencedirect.com/science/journal/00098981
3) Clinical Biochemistry, https://www.sciencedirect.com/science/journal/00099120
4) Circulation, http://ovidsp.ovid.com/ovidweb.cgi?T=JS&MODE=ovid&NEWS=n&PAGE=toc&D=ovft&AN=00003017-000000000-00000
5) Blood, https://ashpublications.org/blood/issue-covers/volume/
6) Journal of Lipid Research, http://www.jlr.org/
7) New England Journal of Medicine, http://www.nejm.org/
8) Lancet, http://search.ebscohost.com/direct.asp?db=ccm&jid=%22LAN%22&scope=site
9) Journal of Clinical Investigation, http://www.jci.org/
1) Cell Metabolism, http://www.cell.chttp://www.jci.orgom/cell-metabolism/redirectUrl/
12) Nature Medicine, http://www.nature.com/nm/index.html
14) Cancer Research, http://cancerres.aacrjournals.org/
*For more information, go to the digital UAB library M9 page: https://catalegclassic.uab.cat/search~S1*spi?/pBLANCO+VACA%2C+FRANCISCO/pblanco+vaca+francisco/-3%2C-1%2C0%2CB/frameset&FF=pblanco+vaca+francisco&5%2C%2C5
SCIENTIFIC CLINICAL LABORATORY SOCIETY WEBSITES:
1) American Association for Clinical Chemistry, www.aacc.org
2) Associació Catalana de Ciències de Laboratori Clínic, www.acclc.cat
3) International Federation of Clinical Chemistry and Laboratory Medicine, www.ifcc.org
4) Sociedad española de Química Clínica y Patología Molecular, www.seqc.es
Software
No especific software is used
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
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| (TEm) Theory (master) | 1 | Spanish | first semester | afternoon |
| (PAULm) Classroom practices (master) | 1 | Spanish | first semester | morning-mixed |
| (SEMm) Seminars (master) | 1 | Spanish | first semester | morning-mixed |