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Cell Biology

Code: 102954
Credits: 6
2026/2027
Degree programme Type Course
Medicine FB 1

Contact lecturer

Name :
Mariona Terradas Ill
Email :
mariona.terradas@uab.cat

Teaching staff

Jordi Ribas Maynou
Marina Rodriguez Muñoz
Maria Oliver Bonet
Montserrat Codina Pascual
Itziar Salaverria Frigola
Alejandro Gella Concustell
Mariona Terradas Ill

Group languages

You can consult this information at the end of the document.

Prerequisites

There are no prerequisites for taking the core subject of Cell Biology as it is a subject in the first semester of the first year. However, in order to ensure proper follow-up and the achievement of the learning objectives set out, it is recommended that students have a basic general knowledge of the structure, chemical composition and functions of the cells.

In addition, students should have good knowledge of English because many of the sources of information on this subject are in this language.

Objectives

The subject of Cell Biology course aims to provide students with a solid understanding of the fundamental principles underlying cell organization and function.

It also aims to establish clear links between this knowledge and the processes that contribute both to the maintenance of health and to the development of disease in humans.

Upon completion of the course, students will be able to:

  • Explain the general characteristics of eukaryotic cells and understand their role as the basic functional units of human tissues and organs.
  • Describe the structure, composition, and functions of cellular membranes; analyze the mechanisms involved in the transport of molecules across membranes; and interpret how alterations in these mechanisms may lead to cellular disorders associated with disease or with drug resistance.
  • Characterize the components of the cell surface involved in intercellular communication, cell recognition, and cell adhesion, and relate them to processes such as metastasis.
  • Describe the composition and functions of the cytosol and its role in the regulation of cellular metabolism.
  • Explain the structure and function of cellular organelles, including those of the endomembrane system as well as mitochondria and peroxisomes, and understand how their dysfunction may affect cellular physiology and contribute to the development of associated diseases.
  • Explain the molecular mechanisms of programmed cell death (apoptosis) and their importance in the development of different types of diseases.
  • Identify the components of the cytoskeleton and explain their role in cellular processes such as cell division, motility, migration, and intracellular transport, as well as the implications of their alteration in neuromuscular diseases and cancer.
  • Analyze the structure and function of the nuclear envelope and understand its relationship with gene expression regulation and certain genetic disorders.
  • Describe chromatin organization and the processes of DNA replication and transcription, integrating these concepts into the understanding of diseases of genetic or epigenetic origin.
  • Describe the main mechanisms of cell signaling, identify the components of signal transduction pathways, and understand how their dysregulation may contribute to the development of diseases such as cancer, diabetes, and autoimmune disorders.
  • Identify the major cell cycle checkpoints and the molecules involved in their regulation, and understand their role in tissue physiology and in the development of cancer.
  • List and describe the different phases of mitotic and meiotic cell division, compare both processes, and explain their relevance to growth, regeneration, and reproduction.
  • Describe the processes of male and female gametogenesis and understand how alterations in these processes may affect fertility.
  • Explain the process of fertilization, integrating the cellular elements involved and the potential causes of reproductive failure.
  • Describe the characteristics and potential of stem cells, as well as their role in tissue regeneration and regenerative medicine.
  • Understand the phenomenon of cellular senescence, its role in ageing, and its relationship with degenerative diseases and cancer.
  • Use the scientific terminology of cell biology accurately and appropriately to communicate concepts clearly and precisely in academic and professional contexts.

Learning outcomes

  1. Identify the basic processes of life on various levels of organisation: cell, organ and individual.
  2. Relate the structure of the different parts of cell to its functioning.
  3. Integrate the functions of the the different cell organelles and structures with the overall functioning of the cell.
  4. Describe the functional and organisational structure of hereditary nuclear and mitochondrial material.
  5. Describe the processes involved in somatic and germinal cell proliferation: mitosis and meiosis.
  6. Describe the processes of cell differentiation, ageing and death.
  7. Identify the basic functional and organisational structure of hereditary nuclear and mitochondrial material.
  8. Explain how alterations to cell components lead to structural and functional alterations to systems of the human organism.
  9. Identify the cell processes that can be the cause or the consequence of pathological manifestations in the organism.
  10. Identify the main cellular processes involved in growth, development and ageing in individuals and their social environment.
  11. Identify the mechanisms and the molecular and cellular processes that can be the cause or the consequence of pathological manifestations in the organism.
  12. Use specific bibliographic sources in cell biology to work independently on acquiring further knowledge.
  13. Maintain and sharpen one's professional competence, in particular by independently learning new material and techniques and by focusing on quality.
  14. Convey knowledge and techniques to professionals working in other fields.
  15. Formulate hypotheses and compile and critically assess information for problem-solving, using the scientific method.
  16. Demonstrate basic research skills.
  17. Communicate clearly, orally and in writing, with other professionals and the media.
  18. Explain the molecular and cellular significance of tissue and system structure.

Contents

Eukaryotic cell; plasma membrane; membrane transport; cytosol; endomembrane system; vesicular transport; energy-converting organelles; programmed cell death (apoptosis); cytoskeleton; extracellular matrix; nucleus and its relationship with the cytoplasm; cell signaling; cell cycle and its regulation; cell division: mitosis and meiosis; male and female gametogenesis; fertilization; stem cells; senescence.


Content Blocks

A. General characteristics of eukaryotic cells: levels of cellular organization and an introduction to cellular compartmentalization and vesicular trafficking.

B. Plasma membrane. Macromolecular organization of the plasma membrane and glycocalyx. Membrane properties: fluidity and asymmetry.

C. Cytosol: composition and functions. Endomembrane system. Components of the endomembrane system. Structure and functions of the rough and smooth endoplasmic reticulum and the Golgi apparatus.

D. Molecular transport: transport of ions, small molecules, macromolecules, and particles. Processes of endocytosis, pinocytosis, potocytosis, phagocytosis, and exocytosis. Endosomes and lysosomes.

E. Mitochondria and peroxisomes: structure and composition. Functions of mitochondria and peroxisomes. Biogenesis. Mitochondrial genome. Import of proteins and lipids from the cytosol. Apoptosis. Alterations of mitochondrial function in cancer.

F. Cytoskeleton. Components of the cytoskeleton: structure and functions. Cytoskeleton-associated proteins: examples and links to disease. Types of intermediate filaments and their distribution among different cell types.

G. Cell adhesion and extracellular matrix. Cell adhesion and junction molecules. Structure and functions of the different types of junctions: tight junctions, anchoring junctions, cell–cell adhesive junctions, cell–extracellular matrix adhesive junctions, and gap junctions. Examples of cell–matrix interactions: lymphocyte extravasation and metastasis.

H. Cell nucleus. Structure of its components: nuclear envelope, nuclear pore complex, nuclear lamina, nuclear matrix, nucleolus, and nucleoplasm. Essential elements of the interphase chromosome. Chromatin structure and organization: relationship with the nuclear lamina and the genetic control of transcription. Main features of DNA replication and transcription. Types of transcripts.

I. Cell signaling. General characteristics. Receptors, growth factors, and associated proteins.

J. Cell cycle: phases and control mechanisms. Mitotic cell division: phases. Alterations of the cell cycle and its regulation: senescence, immortality, and cancer.

K. Meiosis. Meiotic divisions: phases. Biological significance of meiosis: genetic diversity and meiotic recombination. Male gametogenesis. Female gametogenesis. Mechanisms of fertilization. Stem cells.

Learning activities and methodology

Title Hours ECTS Learning outcomes
DEVELOPMENT OF WORK / PERSONAL STUDY 90 3.6 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
LABORATORY PRACTICALS (PLAB) 12 0.48 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
SEMINARS (SEM) 4 0.16 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
THEORY (TE) 33 1.32 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
CLASSROOM PRACTICES (PAUL) 4 0.16 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18

Directed Teaching
Theory lecture (TE). Classroom practices (PAUL). Laboratory practices (PLAB). Specialized seminars (SEM)

Supervised Teaching

Problem based learning

Autonomous Teaching
Personal study. Elaboration of works

Annotation: within the schedule set by the centre or degree programme, 15 minutes of one class will be reserved for students to evaluate their lecturers and their courses or modules through questionnaires.

Assessment

Continuous assessment activities

Title Weight Hours ECTS Learning outcomes
Theory: evaluations written through objective tests: multiple choice items 70% 4 0.16 3, 4, 5, 7, 8, 10, 11, 12, 13, 14, 15, 17
Classroom practices: evaluations written through objective tests of multiple choice items 10% 1 0.04 1, 2, 4, 6, 9, 11, 13, 15, 16, 17
Laboratory practices y seminario: written assessments through activities or test essays of restricted questions and objective tests of multiple choice items 20% 2 0.08 3, 4, 9, 10, 11, 13, 15, 16, 17, 18

Assessment Model

Assessment of the course will be based on the theoretical and practical syllabus described in the course programme. The achievement of the learning objectives and the acquisition of the competencies described in the previous sections will be assessed, including those associated with the theoretical concepts covered in the different blocks, as well as those related to seminars and practical sessions (laboratory and classroom-based).

Continuous Assessment

The course will be assessed continuously throughout the semester through two midterm examinations (P1 and P2), each covering a specific part of the syllabus, together with three activities or tests assessing the content of the laboratory practical sessions (S1, S2 and S3), and one activity (SEM) assessing the content of the two seminar sessions (SEM1 and SEM2).

Each of the two midterm examinations will consist of an objective assessment based on multiple-choice items, designed to evaluate the acquisition of competencies and the integration of the theoretical and practical learning outcomes of the course. Each item will include four response options. The specific characteristics of the response format (single-answer or multiple-answer items) and the marking criteria will be communicated sufficiently in advance through the official course communication channels.

The contents assessed in the midterm examinations are:

P1) Theory corresponding to topics A to E (32%) and classroom practical sessions 1 and 2 (5%).

P2) Theory corresponding to topics F to K (38%) and classroom practical sessions 3 and 4 (5%).

The tests or activities carried out in laboratory practical sessions S1, S2 and S3 and in the seminars will assess the knowledge and competencies acquired during each of these sessions. The activities or tests will be directly related to the work carried out during the session.

In addition, two short continuous-assessment quizzes on specific course contents may be conducted during theory sessions without prior announcement. These activities will have a bonus character and may contribute up to a maximum of 0.1 additional points to the final course grade. These quizzes are not eligible for resit.

The midterm examinations P1 and P2 will take place on the dates scheduled by the Faculty, in the classrooms indicated. The activities or tests corresponding to S1, S2, S3 and SEM will be conducted in the laboratory (for S1, S2 and S3) or in the seminar room (for SEM1 and SEM2) at the end of each session and are not eligible for resit.

The weighting of the different assessment activities in the final course grade is as follows:

P1 (37%) + P2 (43%) + S1 (5%) + S2 (5%) + S3 (5%) + SEM (5%) = 100%

The maximum grade attainable in the course is 10.1 points. The bonus obtained through the short continuous-assessment quizzes will not be taken into account when determining whether the minimum requirements for passing the course or accessing the resit examination have been met.

To pass the course under the continuous assessment system, students must meet the following requirements:

  1. obtain a grade of 5.0 or higher in both P1 and P2;
  2. obtain a weighted average grade of at least 5.0 out of 10 considering P1, P2, S1, S2, S3 and SEM.

Important: Attendance at laboratory practical sessions is compulsory for students enrolled in the course for the first time and following the continuous assessment system. Students repeating the course who obtained a grade higher than 5 in S1, S2 and S3 in a previous academic year are exempt from attending these sessions and will retain the grade obtained previously.

Resit Examination

Students who do not pass the course through continuous assessment may take a resit examination for any midterm examination in which they obtained a grade below 5.0. Passing the resit examination is required for the corresponding component to be included in the final grade calculation. Students who obtained a grade above 5.0 in a midterm examination may also sit the resit examination in order to improve their grade. To do so, they must notify the course coordinator sufficiently in advance. The grade obtained in the resit examination will replace the grade previously obtained through continuous assessment.

To be eligible for the resit examination, students must meet the following requirements:

  1. have taken both midterm examinations (P1 and P2);
  2. obtain a weighted average grade in continuous assessment [P1 (37%) + P2 (43%) + S1 (5%) + S2 (5%) + S3 (5%) + SEM (5%)] equal to or greater than 2.5.

For this purpose, the bonus obtained through the short continuous-assessment quizzes will not be included in the calculation of the continuous assessment grade.

The resit examination will consist of two parts:

  • The first part (37% of the final grade) corresponds to the contents assessed in P1 and therefore covers: theory corresponding to topics A to E (32%) and classroom practical sessions 1 and 2 (5%).
  • The second part (43% of the final grade) corresponds to the contents assessed in P2 and therefore covers: theory corresponding to topics F to K (38%) and classroom practical sessions 3 and 4 (5%).

Students who have passed one of the two midterm examinations with a grade of 5.0 or higher may sit only the part corresponding to the failed midterm examination, without the need to retake the examination already passed.

The final course grade after the resit examination will be calculated using the weightings established for P1, P2, S1, S2, S3 and SEM. For assessment components subject to resit, the grade obtained in the resit examination will replace the grade previously obtained through continuous assessment. For components not subject to resit, the grade obtained through continuous assessment will be retained.

The date and time of the review sessions for both the midterm examinations and the resit examination will be announced immediately after the publication of grades.

Examination Review Procedure

Students may submit complaints regarding the wording of examination questions within two days following the examination date.

The date and time of the review sessions for the midterm examinations and the resit examination will be announced after the publication of grades.


IMPORTANT: The proposed assessment system may be modified if circumstances beyond the University's control affect face-to-face teaching activities.


Single Assessment

Students may opt for the single assessment system in accordance with current Faculty regulations. Single assessment will be based on the same contents, competencies and level of academic demand as the continuous assessment system.

The single assessment examination will be held on the same date and time as the second midterm examination of the continuous assessment system and will consist of two parts:

Theoretical Knowledge (80%)

  • Objective multiple-choice examination designed to assess theoretical knowledge corresponding to blocks A–K and the contents of the classroom practical sessions.

Practical Knowledge (20%)

  • Examination consisting of multiple-choice questions and/or short-answer questions assessing the contents of laboratory practical sessions and seminars.

To pass the course, students must meet the following requirements:

  1. obtain a grade of 5.0 or higher in the theoretical knowledge component;
  2. obtain a weighted final grade of at least 5.0 out of 10 across both components of the examination.

The short continuous-assessment quizzes conducted during theory sessions are exclusive to the continuous assessment system and do not apply to the single assessment pathway. Consequently, the maximum grade attainable under the single assessment system is 10.0 points.

A student who does not attend either the single assessment examination or the resit examination will be recorded as “Not Assessable”.

Resit Examination

Students who do not pass the course through the single assessment system may take the resit examination, provided they meet the requirements established by current academic regulations. The resit examination will consist of the same components and maintain the same weightings as the single assessment examination.

Review Procedure

The review of grades will follow the same procedure established for the continuous assessment system.


IMPORTANT: The proposed assessment system may be modified if circumstances beyond the University's control affect face-to-face teaching activities.

Bibliography

BASIC BIBLIOGRAPHY

1 - \"Biología Molecular de la Célula\". Alberts y col. 6ª edición. Ed. Omega. Barcelona, 2016

2 - \"Molecular Biology of the Cell\". Alberts et al. 7th edition. W W Norton&Company. New York, 2022.

3 - \"La Célula\". Cooper y Hausman. 7ª edición. Ed. Marbán Libros S.L. Madrid, 2017

4 - \"The Cell\". Cooper & Hausman 7th edition, Sinauer Associetes (Oxford University Press), 2017

5 - \"Introducción a la Biología Celular\". Alberts y col. 3ª ed. Ed. Médica Panamericana. Madrid, 2010

6 - \"Biología Celular Biomédica\" Calvo A. Elsevier. Barcelona, 2015

7 - \"Biología Celular y Molecular\". Karp. 6ª edició. Ed. Mac Graw-Hill Interamericana S.A. Mèxic, 2011

8 - \"Molecular Cell Biology\". Lodish et al. 8th edition. WH Freeman and Company. New York, 2016

9 - \"The World of the Cell\". Becker et al. 7th edition. Pearson. San Francisco, 2008

INTERNET RESOURCES

- Books: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books

- Open access review articles and accessible review articles from the computers of the UAB Network. (If you are outside the campus, through the ARE service, Access to Electronic Resources service)

Software

There is no need for any specific software

Course groups and languages

The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE

Type of teaching Group Language Semester Shift
(PAUL) Classroom practices 1 Catalan first semester morning-mixed
(PLAB) Practical laboratories 1 Catalan first semester morning-mixed
(SEM) Seminars 1 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 1 Catalan first semester morning-mixed
(PAUL) Classroom practices 2 Catalan first semester morning-mixed
(PLAB) Practical laboratories 2 Catalan first semester morning-mixed
(SEM) Seminars 2 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 2 Catalan first semester morning-mixed
(PAUL) Classroom practices 3 Catalan first semester morning-mixed
(PLAB) Practical laboratories 3 Catalan first semester morning-mixed
(SEM) Seminars 3 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 3 Catalan first semester morning-mixed
(PAUL) Classroom practices 4 Catalan first semester morning-mixed
(PLAB) Practical laboratories 4 Catalan first semester morning-mixed
(SEM) Seminars 4 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 4 Catalan first semester morning-mixed
(PAUL) Classroom practices 5 Catalan first semester afternoon
(PLAB) Practical laboratories 5 Catalan first semester morning-mixed
(SEM) Seminars 5 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 5 Catalan first semester morning-mixed
(PAUL) Classroom practices 6 Catalan first semester afternoon
(PLAB) Practical laboratories 6 Catalan first semester morning-mixed
(SEM) Seminars 6 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 6 Catalan first semester morning-mixed
(PAUL) Classroom practices 7 Catalan first semester afternoon
(PLAB) Practical laboratories 7 Catalan first semester morning-mixed
(SEM) Seminars 7 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 7 Catalan first semester morning-mixed
(PAUL) Classroom practices 8 Catalan first semester afternoon
(PLAB) Practical laboratories 8 Catalan first semester morning-mixed
(SEM) Seminars 8 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 8 Catalan first semester morning-mixed
(PAUL) Classroom practices 9 Catalan first semester afternoon
(PLAB) Practical laboratories 9 Catalan first semester afternoon
(SEM) Seminars 9 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 9 Catalan first semester afternoon
(PAUL) Classroom practices 10 Catalan first semester morning-mixed
(PLAB) Practical laboratories 10 Catalan first semester afternoon
(SEM) Seminars 10 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 10 Catalan first semester afternoon
(PLAB) Practical laboratories 11 Catalan first semester afternoon
(SEM) Seminars 11 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 11 Catalan first semester afternoon
(PLAB) Practical laboratories 12 Catalan first semester afternoon
(SEM) Seminars 12 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 12 Catalan first semester afternoon
(PLAB) Practical laboratories 13 Catalan first semester afternoon
(SEM) Seminars 13 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 13 Catalan first semester afternoon
(PLAB) Practical laboratories 14 Catalan first semester afternoon
(SEM) Seminars 14 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 14 Catalan first semester afternoon
(PLAB) Practical laboratories 15 Catalan first semester afternoon
(SEM) Seminars 15 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 15 Catalan first semester afternoon
(PLAB) Practical laboratories 16 Catalan first semester afternoon
(SEM) Seminars 16 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 16 Catalan first semester afternoon
(PLAB) Practical laboratories 17 Catalan first semester morning-mixed
(SEM) Seminars 17 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 17 Catalan first semester morning-mixed
(PLAB) Practical laboratories 18 Catalan first semester afternoon
(SEM) Seminars 18 Catalan first semester afternoon
(PLABs) Suport a les pràctiques de laboratori 18 Catalan first semester afternoon
(PLAB) Practical laboratories 19 Catalan first semester morning-mixed
(SEM) Seminars 19 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 19 Catalan first semester morning-mixed
(PLAB) Practical laboratories 20 Catalan first semester morning-mixed
(SEM) Seminars 20 Catalan first semester morning-mixed
(PLABs) Suport a les pràctiques de laboratori 20 Catalan first semester morning-mixed
(TE) Theory 101 Catalan/Spanish first semester afternoon
(TE) Theory 102 Catalan/Spanish first semester morning-mixed
(TE) Theory 103 Catalan/Spanish first semester morning-mixed
(TE) Theory 104 Catalan/Spanish first semester morning-mixed