
Immunology of Infectious Diseases
Code: 101007Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Microbiology | OP | 4 |
Contact lecturer
- Name :
- Roger Colobran Oriol
- Email :
- roger.colobran@uab.cat
Teaching staff
- Julian Miguel Blanco Arbues
- Javier Martinez Picado
- Christian Brander Silva
- Pere Joan Cardona Iglesias
- Roger Colobran Oriol
- Jesús Aranda Rodriguez
Teaching staff (external to UAB)
- Carlota Dobaño
- Hernando del Portillo
- Esteban Veiga Chacón
- Alfred Cortés
Group languages
You can consult this information at the end of the document.
Prerequisites
To access to study "Immunology of Infectious Diseases", the student must have attained the learning skills of Immunology in the course corresponding to their degree.
For non-UAB students, it is strongly recommended to have previously completed a basic immunology course before enrolling in Immunology of Infectious Diseases.
Objectives
BLOCK 1
1.1 Review of the immune response
- Review of the main aspects of the innate and adaptive immune response.
- Review and further study of the mucosa-associated immune system (MALT).
BLOCK 2
2.1 Immune response to viruses
- Understand the core concepts related to antiviral immunity.
- Identify and characterize the mechanisms of innate and adaptive immunity involved in the defense against viral infections.
2.2 Inborn errors of immunity (primary immunodeficiencies) causing severe viral infections
- Learn about genetic defects affecting immune system molecules that are key for defense against viruses.
- Relate the consequences of these genetic defects to the concepts explained in the section on the immune response to viruses.
2.3 Specialist seminars
BLOCK 3
3.1 Immune response to bacteria
- Understand the core concepts related to antibacterial immunity.
- Identify and characterize the mechanisms of innate and adaptive immunity involved in the defense against bacterial infections.
- Distinguish between the immune response to intracellular and extracellular bacteria.
3.2 Inborn errors of immunity (primary immunodeficiencies) causing severe bacterial infections
- Learn about genetic defects affecting immune system molecules that are key for defense against bacteria.
- Relate the consequences of these genetic defects to the concepts explained in the section on the immune response to bacteria.
3.3 Specialist seminars
BLOCK 4
4.1 Immune response to fungi
- Understand the core concepts related to antifungal immunity.
- Identify and characterize the mechanisms of innate and adaptive immunity involved in the defense against fungal infections.
4.2 Inborn errors of immunity (primary immunodeficiencies) causing severe fungal infections
- Learn about genetic defects affecting immune system molecules that are key for defense against fungi.
- Relate the consequences of these genetic defects to the concepts explained in the section on the immune response to fungi.
BLOCK 5
5.1 Immune response to parasites
- Understand the core concepts related to immunity against parasites.
- Identify and characterize the mechanisms of innate and adaptive immunity involved in the defense against parasitic infections.
5.2 Specialist seminars
Learning outcomes
- CM13 (Plan diagnostic and control strategies for infectious diseases from a global perspective and integrating clinical and epidemiological data to provide innovative responses to the challenges, needs and demands of society.) Plan diagnostic and control strategies for infectious diseases from a global perspective and integrating clinical and epidemiological data to provide innovative responses to the challenges, needs and demands of society.
- CM14 (Integrate knowledge and skills in the field of microbiology applied to health, working individually and in groups, to prepare and present in writing or orally and publicly a scientific work either in English or in one's own language or others.) Integrate knowledge and skills in the field of microbiology applied to health, working individually and in groups, to prepare and present in writing or orally and publicly a scientific work either in English or in one's own language or others.
- KM19 (Identify the cellular and molecular relationships established between a microorganism or parasite and its host, including physiological and pathological mechanisms of defence and host response.) Identify the cellular and molecular relationships established between a microorganism or parasite and its host, including physiological and pathological mechanisms of defence and host response.
- KM21 (Indicate the main measures for the prevention and control of pathogenic microorganisms.) Indicate the main measures for the prevention and control of pathogenic microorganisms.
- SM19 (Use bibliography or internet tools, both in English and in one's own language or others, for the study of pathogenic microorganisms and their control.) Use bibliography or internet tools, both in English and in one's own language or others, for the study of pathogenic microorganisms and their control.
- SM20 (Apply appropriate methods for the identification, diagnosis and control of microbial agents and their genetic or metabolic components in clinical samples or food.) Apply appropriate methods for the identification, diagnosis and control of microbial agents and their genetic or metabolic components in clinical samples or food.
Contents
BLOCK 1
1.1 Overview of the immune response.
-Overview of innate immune response: cells of innate immunity, PRRs, PAMPs, DAMPs, complement system, natural killer cells, epithelial barriers, the inflammatory response, the antiviral response.
-Overview of adaptive immune response: Antigen presentation to T lymphocytes, B-cell response, T-cell dependent antibody response, T-cell independent B cell response, T cell response, T cell activation, differentiation and functions of CD4+ effector T cells, differentiation and functions of CD8+ effector T cells.
-Overview of mucosal immunology (MALT): MALT, structure of GALT, small vs large intestine, lamina propria, peyer patches, M cells, innate immunity in GALT, adaptive immunity in GALT, lymphocyte homing in GALT, humoral response in GALT (IgA), T cell response in GALT.
BLOCK 2
2.1 Immune response to viruses.
-General characteristics of virus, tropism, kinetics of immune response to viral infections, innate immunity against virus, viral danger signals, virus recognition by innate immunity, type-I interferons, the antiviral response, plasmacytoid dendrític cells, natural killer cells.
-Adaptive antiviral immune response: humoral response, antibodies, kinetics of antibody response in viral infection, antibody-dependent enhancement, T-cell response against virus, cross-presentation, cytotoxicity, inhibitory mechanisms, T-cell exhaustion, memory cells.
2.2 Inborn errors of immunity (IEI, also known as primary immunodeficiencies) that cause severe viral infections.
-TLR3 deficiency underlying herpes simplex encephalitis, RNA polymerase III (Pol III) deficiency underlying severe varicella zoster infection, IEI predisposing to EBV infection, IEI underlying severe papillomavirus infections, IEI predisposing to severe influenza virus infections.
2.3 Seminars by specialists.
BLOCK 3
3.1 Immune response to bacteria.
-Immune response to extracellular bacteria: General concepts about bacteria, innate immune response to extracellular bacteria: TLRs, NLRs, inflammasome and pyroptosis, role of phagocytes, neutrophils and NETs. Adaptive immune response to extracellular bacteria: humoral immune response, cellular immune response (CD4 T cells, Th17 cells), pathological consequences of immune responses to extracellular bacteria.
-Immune response to intracellular bacteria: Clinical characteristics of infections with intracellular bacteria, innate immune response: autophagy, inflammasome, role of interferons, NK cells. Adaptive immune response: development and functions of Th1 cells, role of Th17 cells, role of CD8 T cells; granulomas (formation, structure, composition, dynamics).
3.2 Inborn errors of immunity (primary immunodeficiencies) that cause severe bacterial infections.
-Inborn errors of Immunity (IEI) predisposing to extracellular bacterial infections: IRAK4 and MYD88 deficiencies underlying pyogenic bacterial infections. RPSA deficiency causing isolated congenital asplenia and infections. IEI of IL6 receptor and severe bacterial infections. IEI of the complement system and extracellular bacterial infections.
-Inborn errors of Immunity (IEI) predisposing to intracellular bacterial infections: Mendelian susceptibility to mycobacterial disease (MSMD): impairment of IFN-gamma production or response, IL12R deficiency, IL23R deficiency, other defects.
3.3 Seminars by specialists.
BLOCK 4
4.1 Immune response to fungi.
- Mycobioma, fungal infections in humans, fungi PAMPs, detecting fungi by PRRs (c-type lectin receptors), innate immunity (macrophages and DCs), cellular adaptive immune response against fungal infections (role of Th17 cells), humoral adaptive immunity in fungal infections.
4.2 Inborn errors of immunity (primary immunodeficiencies) that cause severe fungal infections.
- CARD9 deficiency and severe fungal infections, IL17-IL17R deficiencies and chronic mucocutaneous candidiasis (CMC), AIRE deficiency and CMC, STAT1 gain-of-function mutations and CMC.
BLOCK 5
5.1 Immune response to parasites.
-General aspects of the immune response to parasites. Immune response to helminths: ILC2 cells, stromal cells and type 2 cytokines (TSLP, IL25, IL33), Th2 cells (IL4, IL13, IL5), eosinophils, basophils, mast cells and M2 macrophages, B cell response (IgE) and mast cells.
5.2 Seminars by specialists.
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Master classes | 30 | 1.2 | CM13, KM19, KM21, SM20 |
| Data interpretation from an article or a problem | 20 | 0.8 | SM19, SM20 |
| Classroom practicals | 12 | 0.48 | KM19, SM19 |
| Learning consolidation: study | 50 | 2 | KM19, SM19 |
| Preparation of oral presentation | 17 | 0.68 | CM14, SM19 |
| Preparation of written report | 17 | 0.68 | CM14, SM19 |
Teaching methodology of the course
LECTURES:
The topics included in the different blocks will be taught in approximately 30 sessions. Some of these sessions will be delivered by invited lecturers and specialists in the clinical research field of diseases caused by pathogens. The theoretical content of the course programme will be delivered by the course coordinator in the form of lectures supported by audiovisual material. The presentations used in class by the lecturer will be made available in advance on the course Virtual Campus. The course coordinator will always be present in the classroom, regardless of whether the session is delivered by the coordinator or by an invited lecturer. In the case of sessions delivered by invited lecturers, the course coordinator will briefly introduce the speaker and moderate the subsequent discussion.
AUTONOMOUS LEARNING:
Autonomous learning will be based on achieving the specific learning competences that will be presented at the beginning of each block into which the course programme is divided. Students are advised to regularly consult the books, articles, and videos recommended in class or listed in the bibliography section of this teaching guide, in order to consolidate and clarify, if necessary, the contents explained in class.
COOPERATIVE LEARNING:
Cooperative learning sessions will be scheduled as classroom practical sessions. Students will be divided into groups, and each group will work on a specific topic. The tasks of each group will be:
- To prepare an oral presentation: selecting the key aspects of the topic and presenting them to the rest of the class.
- In connection with the oral presentation, to prepare an infographic accompanied by a descriptive summary.
Details of the assignment will be provided during the course presentation.
Attendance at the cooperative learning sessions is compulsory. There will be a maximum of 10 classroom practical sessions during the course. Attendance will be monitored. A maximum of two absences will be allowed, provided that they are duly justified; supporting documentation will be required.
CLASS ATTENDANCE:
This is an on-site course. This means that the course is designed for students to attend all classes in person. Classroom attendance facilitates understanding of the content and helps students distinguish which information in the supporting slides is essential and which is complementary.
However, attendance will not be monitored during the lectures. Therefore, strictly speaking, attendance is not compulsory, although it is highly recommended.
As explained above, attendance at the classroom practical sessions is compulsory.
USE OF ARTIFICIAL INTELLIGENCE (AI) BY STUDENTS:
Following the recommendations of the UAB, the model for the use of AI in this course is detailed below. This course follows a model in which restricted use of AI by students is permitted. This restricted use consists of the following: for this course, the use of Artificial Intelligence (AI) technologies is permitted for supporting tasks related to the preparation of classroom practical sessions, such as bibliographic or information searches, text correction or translation, and image generation. Students must clearly identify which parts have been generated using this technology, specify the tools used, and include a critical reflection on how these tools have influenced the process and the final outcome of the activity. Lack of transparency regarding the use of AI in this assessed activity will be considered a breach of academic honesty and may result in a partial or total penalty in the grade for the activity.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Presentation of team work | 30% | 1 | 0.04 | CM14, SM19 |
| Partial Examination 2 | 35% | 1.5 | 0.06 | CM13, KM19, KM21, SM20 |
| Partial Examination 1 | 35% | 1.5 | 0.06 | CM13, KM19, KM21, SM20 |
The assessment of the course will be individual and continuous, through activities that will evaluate:
- The student’s individual learning through partial exams.
- Cooperative learning through the training activities scheduled in the classroom practical sessions, including the oral presentation of a topic in accordance with the course competences.
The assessment activities scheduled for the course Immunology of Infectious Diseases are as follows:
Partial exams: two partial exams. Each exam will account for 35% of the final grade, representing 70% of the final grade between the two partial exams. These will be multiple-choice exams with a minimum of 30 questions, each with 5 options and only one correct answer. In the correction, 1/5 of the value of each question will be deducted for each incorrect answer. To pass this part of the course, the average grade of the two partial exams must be equal to or higher than 5. Students must obtain a minimum grade of 4 in each partial exam in order for the two exams to be averaged.
Cooperative learning: this will be organised as cooperative group work in groups of 3–6 students. The aim is for students to develop their self-learning skills, their ability to search for and select information, and, ultimately, their ability to synthesize information and communicate orally and in writing. The ability to work in a group will also be assessed.
The assessment of cooperative learning will represent 30% of the final grade for the course. The grade for the group work will take into account the content of the work, its format, the oral presentation, and the subsequent discussion.
To pass this part of the course, the cooperative learning grade must be equal to or higher than 5.
The final grade for the course will consist of the score obtained in the two partial exams (70% of the grade) plus the score obtained in the cooperative learning assignment (30% of the grade).
OBSERVATIONS:
- If a student does not pass one of the partial exams, or wishes to improve their grade, they will have the option of taking a final exam organised by partial exam sections. In other words, the student may choose to take only one of the partial exam sections or both, as appropriate. The format of the resit exam may be multiple-choice and/or short-answer questions. The format of the resit exam will be announced in advance.
- Taking the exam in order to improve a grade implies waiving the previous grade.
- Failure to attend any of the assessment activities must be justified. Failure to attend any of the partial exams, regardless of the reason, even if justified, means that the student will have to retake that partial exam during the final/resit exam.
- In order to be eligible for the resit exam, students must have previously been assessed in a set of activities whose weight is equivalent to at least two thirds of the total grade for the course. Therefore, students will receive a grade of “Not Assessable” when the assessment activities completed account for less than 67% of the final grade.
-
SINGLE ASSESSMENT:
Students have the option to request single assessment. Single assessment consists of the following:
- Students waive the option of taking the two partial exams separately and will instead take a single exam (single assessment exam) on the same date as the second partial exam. This exam will cover the content of the entire course and will represent 70% of the final grade. To pass this part of the course, the grade of the single assessment exam must be equal to or higher than 5. The format of the exam may be multiple-choice and/or short-answer questions. The format of the single assessment exam will be announced in advance.
- RESIT: the same resit system as for continuous assessment will apply.
- Students who choose single assessment must also complete the cooperative learning component, which represents 30% of the final grade, and must attend the classroom practical sessions, which are compulsory for all students.
- Students who choose single assessment must inform the course coordinator before the end of September.
IMPORTANT: Any irregularity committed during an assessment activity (such as academic fraud, plagiarism, or the improper use of AI, unless such use is expressly authorised in the course guide) that may lead to a significant change in the grade will result in that assessment activity being awarded a grade of 0. If the course guide establishes that obtaining a minimum grade in that assessment activity is an essential requirement for passing the course, or if several irregularities occur in assessment activities within the same course, the final grade for the course will be 0. In addition, disciplinary proceedings may be initiated against any student who commits any of these irregularities.
Bibliography
Primer to the Immune Response. 2nd Edition, by Tak W. Mak, Mary Saunders and Bradley Jett, ELSEVIER (2014). ISBN: 9780123852458
Review of Medical Microbiology and Immunology by W. Levinson, P. Chin-Hong, E.A. Joyce, J. Nussbaum, B. Schwartz. McGraw-Hill, 18th edition, (2024). ISBN-13: 978-1260116717.
Deja Review Microbiology and Immunology. E. Chen, S. Kasturi. McGraw-Hill Ed. 2nd ed (2010). ISBN-13: 978-0071627153.
Elsevier's Integrated Review Immunology and Microbiology: With STUDENT CONSULT Online Access, by Jeffrey K. Actor - Elsevier Science Health Science Division (2012). ISBN: 978-0323074476.
BRS Microbiology and Immunology, by Arthur G. Johnson, Richard J. Ziegler, Louise Hawley. Lippincott Williams & Wilkins 7th (2024). ISBN: 9781975220457.
Janeway's Immunobiology by K. Murphy, C. Weaver. Ltd/Garland Science, NY & London, 10th ed (2026). ISBN: 9780815345053.
Kuby Immunology (with web support) by J. Punt, S. Stranford, P Jones and J. Owen.W.H. Freeman and Co. Ltd, 8th ed (2018). ISBN13: 9781319114701
Cellular and Molecular Immunology by Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai, Saunders, 11th ed (2025). ISBN13: 978-0323757485.
Roitt's Essential Immunology, by Peter Delves, Seamus Martin, Dennis Burton, Ivan Roitt, Wiley-Blackwell Ed., 13th ed (2017). ISBN 9781118415771.
Principles of Mucosal Immunology (Society for Mucosal Immunology), by Phillip D. Smith, Thomas T. McDonald, Richard S. Blumberg Ed. Garland Science 2nd ed. (2020). ISBN 9780815345558.
Mim's Pathogenesis of Infectious disease. A.A; Nash, R.G. Dalziel & J. R. Fitzgerald. Academic Press Ed. 6th Edition. (2015). EBook ISBN: 978012397781; Paperback ISBN: 9780123971883
Principles of Molecular Virology.A.J Cann. Academic Press Ed. 6th Edition. (2016). EBook ISBN: 9780128019559; Paperback ISBN: 9780128019467.
Unifying Michobial Mechanisms. M. F. Cole. Garland Science 1st ed. (2019). eBook ISBN: 9780429262777.
Software
Microsoft Office is sufficient to carry out this subject.
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TE) Theory | 74 | English | first semester | morning-mixed |
| (PAUL) Classroom practices | 741 | English | first semester | morning-mixed |