
Molecular Pharmacology
Code: 100902Credits: 6
| Degree programme | Type | Course |
|---|---|---|
| Biochemistry | OP | 4 |
Contact lecturer
- Name :
- Jordi Ortiz De Pablo
- Email :
- jordi.ortiz@uab.cat
Teaching staff
- Alberto Fernández Arriba
- José Miguel Lizcano De Vega
- Jordi Ortiz De Pablo
- Roser Masgrau Juanola
Group languages
You can consult this information at the end of the document.
Prerequisites
Good knowledge of the principles and competences of initial courses in Biochemistry and signal transduction
Objectives
Molecular Pharmacology is included in therapeutic applications and is studied in the fourth year of the Degree in Biochemistry.
Students will learn about some important endogenous molecular targets susceptible to pharmacological use and / or modulation and the target interaction with the main drug families.
In order to achieve these objectives, the aim is to familiarize the student with the terminology and biochemical concepts related to drug development, the binding of drugs to receptors and / or targets, and drug actions on intracellular signaling pathways and related physiological responses.
Learning outcomes
- CM39 (Explain alterations in the pre- and postimplantation development of embryos, procedures for identifying vaccine and pharmacological targets, and the mechanisms of various types of drugs.) Explain alterations in the pre- and postimplantation development of embryos, procedures for identifying vaccine and pharmacological targets, and the mechanisms of various types of drugs.
- CM40 (Deliver a public oral presentation on therapeutic applications of biochemistry.) Deliver a public oral presentation on therapeutic applications of biochemistry.
- KM40 (Identify the mechanisms of drugs.) Identify the mechanisms of drugs.
- SM42 (Use digital resources in identifying therapeutic, vaccine and diagnostic targets, and also to evaluate drugs.) Use digital resources in identifying therapeutic, vaccine and diagnostic targets, and also to evaluate drugs.
- SM43 (Apply technologies for embryo manipulation, gene therapy and the production of transgenic drugs, vaccines and animals.) Apply technologies for embryo manipulation, gene therapy and the production of transgenic drugs, vaccines and animals.
- SM44 (Analyse the ethical and legal aspects of cell therapy in humans, embryo manipulation, and the requirements for R+D, clinical and preclinical trials, and applications for patents and licences.) Analyse the ethical and legal aspects of cell therapy in humans, embryo manipulation, and the requirements for R+D, clinical and preclinical trials, and applications for patents and licences.
Contents
1. Molecular Pharmacology and drug development
The different current techniques of new drug discovery and in the phases of drug development will be reviewed.
2. Quantitative aspects of drug-receptor interaction
The concepts of drug-receptor interaction, radioligand binding techniques, types of agonists and antagonists, efficacy and desensitization will be worked on theoretically and practically. Allosterism and oligomerization in receptors and signaling bias will be introduced.
3. Absorption, transport and metabolism of drugs
The routes of administration, transport, distribution, metabolism and clearance, and variability in pharmacological responses will be introduced.
4. Molecular mechanisms of drugs that act on ion transporters and pumps: representative examples
Examples of drugs such as cocaine and ecstasy, antidepressants such as fluoxetine, diuretics such as furosemide, cardiotonics such as digoxin and gastric secretion inhibitors such as omeprazole will be reviewed.
5. Molecular mechanisms of drugs that act on ion channels: representative examples
Examples of drugs such as local anesthetics, antihypertensives such as dihydropyridines and anxiolytics and hypnotics from the benzodiazepine and barbiturate family will be analyzed.
6. Molecular mechanisms of drugs that act on receptors: representative examples
Drugs such as the antiasthmatics salbutamol and salmeterol, the antihistamines H1 and corticosteroids for allergies and the drugs discovered by Nobel laureate James Black will be reviewed.
7. Molecular mechanisms of drugs that act on enzymes: representative examples
Drugs such as aspirin, paracetamol and ibuprofen, cholesterol synthesis inhibitors, statins, antihypertensive inhibitors of the angiotensin converting enzyme and vasodilators such as organic nitrates and phosphodiesterase inhibitors will be reviewed.
8. Integration of concepts: molecular pharmacology of tumor processes
This topic will cover the biochemistry of chemotherapy, monoclonal antibodies, soluble receptors, kinase activity receptor inhibitors, multi kinase inhibitors, and drugs for hormone-dependent tumor processes.
Learning activities and methodology
| Title | Hours | ECTS | Learning outcomes |
|---|---|---|---|
| Essay and prepration of oral presentation of the molecular aspects of a drug | 22 | 0.88 | CM39, CM40, KM40, SM42, SM43, SM44 |
| Practical labs | 12 | 0.48 | CM39, KM40, SM42, SM43, SM44 |
| Tutorials | 2 | 0.08 | CM39, CM40, KM40, SM42, SM44 |
| Activities at Aula Moodle | 1 | 0.04 | CM39, KM40, SM42, SM44 |
| Preparation of practical labs | 5 | 0.2 | CM39, KM40, SM42, SM44 |
| Specialized seminars (Oral presentations of assays about drugs) | 4 | 0.16 | CM39, CM40, KM40, SM42, SM44 |
| Lectures | 36 | 1.44 | CM39, KM40, SM42, SM44 |
| Active studying at home | 56 | 2.24 | CM39, KM40, SM42, SM44 |
The most relevant training activities of the subject are divided into theoretical classes, practical classes in the laboratory and with the computer, specialized seminars (drug presentations by students) and tutorials.
Theory classes
The teachers will give an overview of the subject under study and will make an oral presentation with the help of audiovisual material to develop the aspects of special complexity. At the same time, they can also comment on the material available for the other activities and propose different activities to achieve the learning of the contents and the transversal competences of the subject.
Practical laboratory and computer work
Small groups of students will carry out an experimental work divided in three sessions of four hours each. The aim of these practices is for students to know basic experimental pharmacological techniques, participating in the design of the experimental protocol that will later be performed in the laboratory. The results obtained will be analyzed and discussed with the aid of computers in the last session and may also be contextualized or discussed in theory classes and provide matter for exams. Attendance to all sessions is mandatory.
Specialized seminars with drug presentations by students
A student work will be carried out on different pharmacological and biochemical aspects of a drug in a transversal way. During the first weeks of the semester in the Moodle Classroom there will be a list of drugs that will be worked on in each course, and in groups of two students will be able to express their preferences. The work will be carried out throughout the semester and, in the last days and within the activities scheduled for the subject, there will be a presentation of a maximum of 15 minutes for each work including the questions of the subsequent discussion in which all students and teachers of the subject will be able to participate. Teachers may decide whether oral presentations take place in the classroom or with videoconference. Attendance to all the sessions is mandatory.
Tutorials
A tutor will advise and guide students in carrying out the work about a drug or will resolve doubts on the contents of the subject. Students and their tutor will agree on when and where the tutorials will take place, which can also be done through Teams and Moodle Classroom.
Use of Artificial Intelligence
The use of Artificial Intelligence (AI) technologies is permitted as an integral part of the development of the work, provided that the final result reflects a significant contribution by the student in the analysis and personal reflection. The student must clearly identify which parts have been generated with this technology, specify the tools used and include a critical reflection on how these have influenced the process and the final result of the activity. The lack of transparency in the use of AI will be considered a lack of academic honesty and may lead to a penalty in the grade of the activity, or greater sanctions in serious cases.
Assessment
Continuous assessment activities
| Title | Weight | Hours | ECTS | Learning outcomes |
|---|---|---|---|---|
| Specialized seminars (Essay and oral presentation of molecular aspects of a drug) | 22 % | 4 | 0.16 | CM39, CM40, KM40, SM42, SM44 |
| Exam 1 (Themes 1-4 and practical lessons) | 34 % | 2 | 0.08 | CM39, KM40 |
| Exam 2 (Themes 4-8) | 34 % | 2 | 0.08 | CM39, KM40 |
| Pratical lessons avaluation (professional actitude, essay and protocol) | 10 % | 4 | 0.16 | CM39, KM40, SM42, SM43, SM44 |
The evaluation will be individual and continuous. There will be different evaluation activities throughout the semester:
Laboratory practices
The teaching staff will evaluate laboratory practice competences through continuous assessment during the three practice sessions, the creation and completion of an experimental protocol and a final report. These assessments will consist of 10% of the overall grade of the subject. Attendance to these sessions is mandatory and not recoverable.
Work about a drug
The students will have to work in groups of two summarize information about a drug independently but also with tutoring. At the end of the subject, a short-written report and an oral presentation of this work will be required. From all these activities, a work score will be obtained that will represent 22% of the final grade of the subject. Attendance at the oral presentations of all works on a drug is mandatory and non-recoverable.
Partial exams 1 and 2
There will be two exams during the semester. The first corresponding to the first four topics of the subject and to the practices in the laboratory and with a weight of 34% on the final grade of the subject. The second exam will be of subjects 5-8 and will also have a weight of 34%.
Retake exam
There will be a retake exam for students who fail one or both midterm exams (grade below 5) or that want to improve the grade obtained. To participate in this exam, you must have previously been assessed in a set of activities whose weight is equivalent to a minimum of two thirds of the total grade of the subject. To pass, students must have achieved a minimum grade of 4 in all midterm exams, and a weighted average of 5 in total. Students who retake a midterm exam will automatically waive the grade they obtained in the prior midterm exam to retake. Laboratory practice grades and work about a drug are not recoverable. The recovery exam will also evaluate the teaching objectives worked on in all the different training activities (theory classes, laboratory practices and specialized seminars).
Exam format
The exams will consist of written questions to answer in a limited space and time, which could be complemented with test and other evaluation modalities.
Global evaluation
The final mark of the subject will be obtained from the marks of the laboratory practices (10%), work about a drug (22%), exam 1 (34%) and exam 2 (34%). The retake exam will therefore have a maximum weight of 65%. The subject will be considered passed when the weighted score of all sections exceeds 5, and a mark equal to or higher than 4 has been taken in each of the partial exams (1 and 2) or in the corresponding part of the retake exam.
Non-Assessable
The grade of \"non-Assessable\" will be obtained when the assessment activities carried out have a weighting of less than 67% in the final grade or when the absence from the compulsory practices and activities is greater than 20% of the scheduled sessions.
Voluntary use of English
To encourage the voluntary use of English by students, 0.3 points out of 10 will be added to all assessment activities if English is used correctly.
Unique assessment
Students who have requested a single assessment according to the procedures established by the UAB will be able to do it for all the activities of the subject except for attendance at practical and oral presentations of the work on a drug, as these are mandatory activities and cannot be recovered. The single assessment will be structured in the same way as the continuous assessment, with the same relative weight of each part. The same system of recovery, review of grades and determination of the \"Non-Assessable\" grade will be applied. The single assessment will be carried out on the same day as the second theory part and will include parts 1 and 2 of the continuous assessment.
Detection of irregularities
The commission of any irregularity in an assessment (academic fraud, plagiarism or improper use of AI, unless such use is expressly authorized in the teaching guide), which may lead to a significant variation in the grade, implies that this assessment will be graded with a 0. In the event that the teaching guide provides that in order to pass the subject it is required to have obtained a minimum grade in this assessment act, the final grade for this subject will be 0. Similarly, if several irregularities are detected in the assessments, the final grade for this subject will be 0. Apart from this, a disciplinary process may be initiated against the student who incurs any of hese irregularities.
Bibliography
- Farmacología H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower, Elsevier 2024
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1fbc57r/alma991010964536306709
- Goodman Gilman: Las bases farmacológicas de la terapéutica. L.L. Bruton, j.S: Lazo, K.L.Parker, McGraw-Hill 2023
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1eqfv2p/alma991010852135106709
- Molecular Neuropharmacology: A foundation for Clinical Neuroscience, 3rd edition. Eric J. Nestler, Steven E. Hyman, Robert C. Malenka. Ed. Mc Graw-Hill 2015
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/avjcib/alma991010526638706709
- Farmacologia Humana, 6ª ed, J. Florez, Masson 2013
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1c3utr0/cdi_askewsholts_vlebooks_9788445825235
- G protein-coupled receptors: Molecular Pharmacology. G. Vauquelin, B. Von Mentzer Willey 2007
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1eqfv2p/alma991003202629706709
- Human drug metabolism. An introduction. 3rd edition, M.D. Coleman. Wiley-Blackwell 2020
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1c3utr0/cdi_askewsholts_vlebooks_9781119458616
- Biochemistry and Molecular Biology Education: Analyzing ligand depletion in a saturation equilibrium binding experiment. pp. 428. E Claro . IUBMB 2006
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1c3utr0/cdi_proquest_miscellaneous_870292742
- Pharmacology in Drug Discovery and Development. 2nd Edition. Terry Kenakin. Academic Press 2017
- https://bibcercador.uab.cat/permalink/34CSUC_UAB/1eqfv2p/alma991010591133206709
Software
Not defined
Course groups and languages
The information provided is provisional until November 30. After this date, you will be able to consult the language of each group through this link. To access the information, you will need to enter the course CODE
| Type of teaching | Group | Language | Semester | Shift |
|---|---|---|---|---|
| (TE) Theory | 34 | Catalan | first semester | morning-mixed |
| (PLAB) Practical laboratories | 341 | Catalan | first semester | afternoon |
| (SEM) Seminars | 341 | Catalan | first semester | morning-mixed |
| (PLABs) Suport a les pràctiques de laboratori | 341 | Catalan | first semester | afternoon |
| (PLAB) Practical laboratories | 342 | Catalan | first semester | afternoon |
| (SEM) Seminars | 342 | Catalan | first semester | morning-mixed |
| (PLABs) Suport a les pràctiques de laboratori | 342 | Catalan | first semester | afternoon |